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FLASH GENE
Symbol MAOB contributors: mct - updated : 03-04-2013
HGNC name monoamine oxidase B
HGNC id 6834
Corresponding disease
MAOA/BD MAOA/B deletion syndrome
Location Xp11.23      Physical location : 43.625.857 - 43.741.721
Synonym name
  • amine oxidase (flavin-containing)
  • tyramine oxidase
    • EC.number 1.4.3.4
    DNA
    TYPE functioning gene
    STRUCTURE 115.87 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2611 - 520 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrain    
     nervecranial nerve  highly
    Reproductivefemale systemuterus  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • FAD binding domain
  • anchored to the outer mitochondrial membrane via C-terminal helical tails
    • mono polymer homomer , heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans C24G6.6
    intraspecies homolog to MAOA
    Homologene
    FAMILY flavin monoamine oxidase family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • degrading amine neurotransmitters
  • catalyzing the oxidative deamination of biogenic and xenobiotic amines and playing an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
  • novel roles for MAOA, MAOB and serotonin in the regulation of intermediate progenitor cells proliferation in the developing brain
  • PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
  • MAOA and MAOB are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide
  • MAOA, and MAOB are dimeric in their membrane-bound forms
  • MAOA and MAOB are mitochondrial-bound proteins, catalyzing the oxidative deamination of monoamine neurotransmitters as well as xenobiotic amines
  • plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism amine , hormone
    signaling neurotransmission
    metabolism of biogenic amine hormones (such as dopamine, serotonin, norepinephrine)
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    FAD
    protein
  • targeting JUN and EGR1 afteractivation by a protein-kinase C MAPK signal transduction pathway
  • PARK2 suppresses the transcription of MAOA, MAOB to control oxidative stress induced by dopamine oxidation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAOA/BD
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    increased brain MAOB activity is associated with Alzheimer disease
    constitutional     --low  
    significantly lower platelet MAOB activity in children with hyperactive, inattentive, and combined subtype of ADHD than in control children
    Susceptibility to Parkinson disease
    Variant & Polymorphism
    Candidate gene
    Marker
  • MAOB platelet protein level may serve as a biomarker for age-related dementia, especially Alzheimer disease
  • increased MAOB protein levels might serve as a surrogate marker for - Parkinson disease
    • Therapy target
    ANIMAL & CELL MODELS