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FLASH GENE

Symbol

PDK2

contributors: mct/npt - updated : 19-12-2017

HGNC name	pyruvate dehydrogenase kinase, isozyme 2
HGNC id	8810

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	16.63 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

provisional

Map	cen - D17S806 /D17S1859 - HOXB3 - ATP6V0A1 - GIP - GNGT2 - PHB - NGFR - D17S1795 - qter
Authors	Mohlke (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002611 11 - 2319 NP_002602 - 407 - 2017 28178523 NM_001199898 12 - 2712 NP_001186827 - 343 - 2017 28178523 NM_001199900 4 - 987 NP_001186829 - 199 - 2017 28178523 NM_001199899 11 - 2511 NP_001186828 - 343 - 2017 28178523

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       lowly Endocrine pancreas       lowly Respiratory lung       lowly Urinary kidney       lowly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta lowly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a C-terminal DW-motif playing a role in mediating communications between the dichloroacetate -, the nucleotide-, and the lipoyl domain-binding sites (Li 2009)

HOMOLOGY

interspecies	homolog to murine Pdk2
	homolog to C.elegans zk370.5

Homologene

FAMILY

PDK/BCKDK protein kinase family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	inhibition of the mitochondrial pyruvate dehydrogenase complexe by phosphorylation of the E1 alpha subunit
	with PDK3 and PDK4 are primary PPARbeta/delta target genes underlining the importance of the receptor in the control of metabolism (Degenhardt 2007)
	regulation of glycolysis by PDK2, PDK4 functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
	PDK1 and PDK2 promote meiotic maturation, as their knockdown disturbs the assembly of the meiotic apparatus, without significantly altering ATP content
	PDK2 and PDK4, key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the DRG leading to painful diabetic neuropathy
	preliminary positive role and potential mechanisms of PDK2 in chondrogenic differentiation of mesenchymal stem cells (MSCs)
	promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of SOX6 and activation of JNK/MAPK/ERK pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with OSBP9L (PDK2 substrate and negative regulator of Akt phosphorylation at the PDK2 site) (Lessmann 2007)
	wild-type TP53 prevents manifestation of the Warburg effect by controlling PDK2
	mitochondrial activation by inhibition of PDK2 suppresses HIF1a signaling and angiogenesis in cancer
	PDK2, a key regulator in metabolic plasticity, phosphorylates PARL and regulates beta cleavage

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive liver   is a potential therapeutic target for nonalcoholic fatty liver disease

ANIMAL & CELL MODELS