| 1 | PARL, PDK2
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| The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism.
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| Shi G, McQuibban GA.
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| Cell Rep 18(6):1458-1472. doi: 10.1016/j.celrep.2017.01.029.
2017
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| 2 | PDK2
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| PDK2 promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of Sox6 and activation of JNK/MAPK/ERK pathway.
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| Wang H, Shan XB, Qiao YJ.
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| Braz J Med Biol Res 50(2):e5988. doi: 10.1590/1414-431X20165988.
2017
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| 3 | PDK2
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| Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.
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| Go Y, Jeong JY, Jeoung NH, Jeon JH, Park BY, Kang HJ, Ha CM, Choi YK, Lee SJ, Ham HJ, Kim BG, Park KG, Park SY, Lee CH, Choi CS, Park TS, Lee WN, Harris RA, Lee IK.
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| Diabetes 65(10):2876-87. doi: 10.2337/db16-0223. Epub 2016 Jul 6.
2016
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| 4 | PDK2, PDK4
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| Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy.
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| Rahman MH, Jha MK, Kim JH, Nam Y, Lee MG, Go Y, Harris RA, Park DH, Kook H, Lee IK, Suk K.
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| J Biol Chem 291(11):6011-25. doi: 10.1074/jbc.M115.699215. Epub 2016 Jan 14.
2016
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| 5 | PDK1, PDK2
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| Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.
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| Hou X, Zhang L, Han L, Ge J, Ma R, Zhang X, Moley K, Schedl T, Wang Q.
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| J Cell Sci 128(13):2319-29. doi: 10.1242/jcs.167049. Epub 2015 May 19.
2015
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| 6 | PDK2, PDK4
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| Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.
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| Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T.
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| Cell Stem Cell 12(1):49-61. doi: 10.1016/j.stem.2012.10.011.
2013
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| 7 | PDK2
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| Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer.
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| Sutendra G, Dromparis P, Kinnaird A, Stenson TH, Haromy A, Parker JM, McMurtry MS, Michelakis ED.
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| Oncogene 32(13):1638-50. doi: 10.1038/onc.2012.198. Epub 2012 May 21.
2013
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| 8 | PDK2, TP53
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| p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.
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| Contractor T, Harris CR.
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| Cancer Res 72(2):560-7. doi: 10.1158/0008-5472.CAN-11-1215. Epub 2011 Nov 28.
2012
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| 9 | PDK2
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| Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.
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| Li J, Kato M, Chuang DT.
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| J Biol Chem 284(49):34458-67. Epub 2009 Oct 15.PMID: 19833728 2009
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| 10 | PDK2
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| Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.
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| Hiromasa Y, Roche TE.
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| Biochemistry 47(8):2298-311. Epub 2008 Jan 26.PMID: 18220414 2008
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| 11 | PDK2, PDK3, PDK4
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| Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
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| Degenhardt T, Saramäki A, Malinen M, Rieck M, Väisänen S, Huotari A, Herzig KH, Müller R, Carlberg C.
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| J Mol Biol 372(2):341-55. Epub 2007 Jul 19.PMID: 17669420 2007
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| 12 | OSBPL9, PDK2
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| Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation.
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| Lessmann E, Ngo M, Leitges M, Minguet S, Ridgway ND, Huber M.
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| Cell Signal 19(2):384-92. Epub 2006 Jul 25.PMID: 16962287 2007
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| 13 | PDK1, PDK2
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| Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.
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| Boulatnikov I, Popov KM.
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| Biochim Biophys Acta 1645(2):183-92. 2003
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| 14 | PDK2, PDK3
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| Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
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| Baker JC, Yan X, Peng T, Kasten S, Roche TE.
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| J Biol Chem 275(21):15773-81. 2000
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| 15 | ATP6V0A1, GIP, GNGT2, B4GALNT2, CALCOCO2, PDK2, PHB, SLC35B1, IGFBP2
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| Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level.
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| Mohlke KL, et al.
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| Genomics 54 : 19-30. 1998
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| 16 | PDK1, PDK2, PDK3
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| Diversity of the pyruvate dehydrogenase kinase gene family in humans.
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| Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM.
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| J Biol Chem 270(48):28989-94. 1995
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