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FLASH GENE

Symbol

HOXB3

contributors: mct - updated : 06-07-2011

HGNC name	homeo box B3
HGNC id	5114

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.3      Physical location : 46.626.232 - 46.651.810
Genatlas name	homeo box B3(2G)
Synonym symbol(s)	HOX2G, HOX2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	25.58 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

confirmed

Map

see HOXB@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002146 4 - 3627 - 431 - 1996 8646877

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Reproductive female system uterus     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-2.7
	homolog to Drosophila Zen

Homologene

FAMILY

antp homeobox family.

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
	potentially playing an essential role in regulating B lymphopoiesis
	plays important roles in embryogenesis and it has a complex transcription profile of mRNAs, non-coding RNAs and anti-sense RNAs

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to DNMT3B and increases its expression and in turn, is recruited to the RASSF1A promoter, resulting in hypermethylation and silencing of RASSF1A expression (

cell & other

REGULATION

Other

multiple non-coding RNAs could be involved in the regulation of HOXB3

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS