Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HOXB3 contributors: mct - updated : 06-07-2011
HGNC name homeo box B3
HGNC id 5114
Location 17q21.3      Physical location : 46.626.232 - 46.651.810
Genatlas name homeo box B3(2G)
Synonym symbol(s) HOX2G, HOX2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 25.58 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status confirmed
Map see HOXB@
Physical map
HOXB1 17q21.3 homeo box B1 HOXB2 17q21.3 homeo box B2 HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6 HOXB7 17q21.3 homeo box B7 HOXB8 17q21.3 homeo box B8 HOXB9 17q21.3 homeo box B9 PRAC 17q21 homeo box B9 HOXB13 17q21.3 homeo box B13 FLJ35808 17q21.33 hypothetical protein FLJ35808 NDP52 17q21.3 hypothetical protein FLJ35808 LOC388399 17 similar to SMT3 suppressor of mif two 3 homolog 2 ATP5G1 17q21.32 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3627 - 431 - 1996 8646877
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Reproductivefemale systemuterus  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-2.7
homolog to Drosophila Zen
Homologene
FAMILY antp homeobox family.
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • potentially playing an essential role in regulating B lymphopoiesis
  • plays important roles in embryogenesis and it has a complex transcription profile of mRNAs, non-coding RNAs and anti-sense RNAs
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to DNMT3B and increases its expression and in turn, is recruited to the RASSF1A promoter, resulting in hypermethylation and silencing of RASSF1A expression (
  • cell & other
    REGULATION
    Other multiple non-coding RNAs could be involved in the regulation of HOXB3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS