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Symbol NGFR contributors: mct/shn/ - updated : 11-10-2017
HGNC name nerve growth factor receptor
HGNC id 7809
Location 17q21.33      Physical location : 47.572.654 - 47.592.382
Synonym name
  • nerve growth factor receptor (TNFR superfamily, member 16)
  • tumor necrosis factor receptor superfamily member 16
  • low affinity nerve growth factor receptor
  • low affinity neurotrophin receptor p75NTR
  • CD271 antigen
  • NGF receptor
  • p75 ICD
  • TNFR superfamily, member 16
  • Gp80-LNGFR
  • Synonym symbol(s) LGNFR, TNFRSF16, p75NTR, CD271, Gp80-LNGFR, p75(NTR)
    TYPE functioning gene
    STRUCTURE 19.72 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D17S1868 - D17S797 - NGFR - D17S943 - D17S1795 - qter
    Text see also NTRK1
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3420 - 427 - -
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrain   highly Homo sapiens
     nerve   predominantly
    Reproductivefemale systemovary  highly
    Respiratorylung   highly Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposewhite   Homo sapiens
    Muscularstriatum    Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    NervousSchwann cell
    cell lineage
    cell lines
    at STAGE
  • N-terminal region containing the leucine-rich repeats along with the transmembrane and cytoplasmic domains of LINGO1 are not required for self-interaction or interaction with APP
  • an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions
  • a serine/threonine-rich region containing the nerve growth factor binding domain
  • a single transmembrane domain
  • a 155-amino acid cytoplasmic domain
  • a cytoplasmic death domain, with unique intracellular structure and downstream signaling partners
  • mono polymer homomer , dimer
    interspecies ortholog to Ngfr, Mus musculus
    ortholog to Ngfr, Rattus norvegicus
  • tumor necrosis factor receptor (TNFR) superfamily
  • CATEGORY enzyme , signaling cytokine growth factor , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
  • type I transmembrane protein (TM1)
  • localized along with the SSTR3 receptor to the primary cilia of the granule cells of the murine dentate gyrus, a center of adult neurogenesis
  • NGFR and NTRK1 are localized in the mitochondrial compartment of undifferentiated human podocytes and in all tissues analyzed including rat central nervous system
  • basic FUNCTION
  • important role in the development and function of sensory neurons
  • mediates neurotrophin-dependent apoptosis
  • involved in light-mediated photoreceptor apoptosis in vivo
  • is the signal transducing element for Myelin-associated glycoprotein
  • initiates intracellular signaling leading either to cell survival or to apoptosis
  • an essential role for p75(NTR)-related signalling in early embryonic morphogenesis
  • role in activity-dependent synaptic plasticity
  • receptor tyrosine kinase, class VI, regulating the myelination process in peripheral nervous system
  • a negative growth regulator within the context of myelin inhibition 5
  • may play a positive role in nerve regeneration
  • involved in the control of neuronal survival versus death and axonal regeneration and growth cone collapse
  • regulator of liver repair
  • binds pro and mature neurotrophins and affects the growth, differentiation and death of the nervous system
  • maintains the specificity of neural connectivity
  • regulator of glucose uptake and insulin resistance
  • unanticipated function of NGFR as a unique regulator of glucose metabolism and insulin sensitivity
  • transcriptional activation of NGFR is under circadian regulation in the nervous system and peripheral tissues, and plays an important role in the maintenance of clock and metabolic gene oscillation
  • influences the proliferation, survival, and differentiation of neuronal precursors and its expression is induced in injured brain, where it regulates cell survival
  • can modulate cell-fate decisions through its highly ramified signaling pathways
  • CELLULAR PROCESS cell life, cell death/apoptosis
    a component
    small molecule
  • extracellular signal-regulated protein kinases 1 and 2
  • Fas-associated phosphatase-1, FAP-1
  • SC-1
  • the six tumor necrosis factor receptor-associated factors, TRAF1-6
  • caveolin 1, cav1
  • zinc finger protein NRIF
  • trkA, trkB and trkC
  • neurotrophin receptor-interacting MAGE homolog, NRAGE and TrkA, TRKA
  • p75NTR-associated cell death executor, NADE
  • ganglioside GT1b
  • necdin and MAGE-H1
  • neurotrophin receptor-interacting MAGE homolog, NRAGE
  • NDN and MAGEH1, are interactors for the intracellular domain of NGFR and the interaction is enhanced by ligand stimulation
  • interleukin 1 receptor-associated kinase, IRAK
  • tumor necrosis factor receptor-associated death domain protein, TRADD, upon nerve growth factor stimulation
  • beta catalytic subunit of cAMP-dependent protein kinase, PKACbeta
  • nerve growth factor, NGF
  • NDN and NSMCE3 target both E2F1 and NGFR to regulate cell viability during brain development
  • Nogo receptor and LINGO-1
  • brain-expressed X-linked 1, Bex1
  • par-3 partitioning defective 3 homolog (C. elegans), PARD3
  • MAGED1 (NGFR adaptor protein, required for developmental apoptosis)
  • SALL2 (SALL2 is a novel NGFR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth)
  • serves as a receptor for the pro-forms of theneurotrophins
  • NPHS1 and NGFR share a partial overlapping expression pattern in the epicardium and subepicardial coronary vessels
  • interactions of RTN4R with its co-receptors LINGO1, NGFR and the myelin inhibitor RTN4 is facilitated by gangliosides
  • is required for the signal transduction of PILRB, which interacted with NGFR upon ligand binding
  • on oligodendroglial cells, LINGO1 interacts with NGFR to constitutively inhibit multiple aspects of oligodendrocyte differentiation
  • RAB5A and RAB31 directly interact with NGFR primarily via helix 4 of the NGFR death domain
  • NTRK1 and NGFR collaborate with each other at the plasma membrane to bind NGF
  • NGFRAP1 interacts with the death domain of NGFR and mediates apoptosis in neural cells in response to nerve growth factor
  • NGFR and NTRK1 interact to enhance neurotrophic signaling
  • NGFR associated predominantly with natively expressed LINGO1 containing immature N-glycans, characteristic of protein that has not completed trans-Golgi-mediated processing
  • neuronal NRDC critically regulates cardiac sympathetic innervation and circulatory dynamics via modulation of NGFR
  • cell & other
    repressed by MYCN (acts directly to repress NTRK1 and NGFR gene transcription)
    Other phosphorylated by PKACbeta
    regulated by the helix-loop-helix transcription factors CLOCK and ARNTL
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in melanomas
    Variant & Polymorphism
    Candidate gene
    Therapy target
    diabetetype 2 
    unanticipated function of NGFR as a unique regulator of glucose metabolism and insulin sensitivity
  • mice with NGF receptor p75 mutation are viable and fertile display markedly decreased sensory innervation, loss of heat sensitivity associated with ulcers in the distal extremities
  • light-induced photoreceptor apoptosis in p75NTR knockout mice is significantly reduced
  • impairment of hippocampal long-term potentiation in p75NTR-deficient mouse
  • mice depleted for p75NTR exacerbate liver pathology and inhibited hepatocyte proliferation in vivo