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FLASH GENE

Symbol

GNGT2

contributors: mct/npt - updated : 01-06-2016

HGNC name	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
HGNC id	4412

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.32      Physical location : 47.283.596 - 47.286.743
Synonym name	G protein cone gamma 8 subunit
	gamma-T2 subunit 2
	G gamma-C
Synonym symbol(s)	GNG8, GNGT8, GBGU, GNG9, G-GAMMA-8, G-GAMMA-C

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	3.15 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031498 4 - 1058 NP_113686 - 69 - DePuy (2006)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye retina     specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

GGL domain

HOMOLOGY

interspecies

homolog to murine Gngt2

Homologene

FAMILY

G protein gamma family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus

basic FUNCTION

playing a crucial role in cone phototransduction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of heterotrimeric G-protein, cone transducin, comprising GNAT2, GNB3 and GNGT2 subunits

INTERACTION

DNA

RNA

small molecule

protein

ARRB1 (functions of ARRB1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signaling for NF-kappaB activation) (Yang 2009)

cell & other

REGULATION

activated by

TH (Liu 2007)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS