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FLASH GENE
Symbol GNGT2 contributors: mct/npt - updated : 01-06-2016
HGNC name guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
HGNC id 4412
Location 17q21.32      Physical location : 47.283.596 - 47.286.743
Synonym name
  • G protein cone gamma 8 subunit
  • gamma-T2 subunit 2
  • G gamma-C
  • Synonym symbol(s) GNG8, GNGT8, GBGU, GNG9, G-GAMMA-8, G-GAMMA-C
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 3.15 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6 HOXB7 17q21.3 homeo box B7 HOXB8 17q21.3 homeo box B8 HOXB9 17q21.3 homeo box B9 PRAC 17q21 homeo box B9 HOXB13 17q21.3 homeo box B13 FLJ35808 17q21.33 hypothetical protein FLJ35808 NDP52 17q21.3 hypothetical protein FLJ35808 LOC388399 17 similar to SMT3 suppressor of mif two 3 homolog 2 ATP5G1 17q21.32 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 FLJ13855 17q21.33 hypothetical protein FLJ13855 EAP30 17q21.33 EAP30 subunit of ELL complex GIP 17q21.31 gastric inhibitory polypeptide IMP-1 17q21.33 IGF-II mRNA-binding protein 1 GALGT2 17q21.3 beta 1,4 N-acetylgalactosaminyltransferase GNGT2 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 NESH 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 PHOSPHO1 17q21.32 phosphatase, orphan 1 LOC124871 17q21.33 hypothetical gene LOC124871 KIAA0924 17q21.32 hypothetical gene LOC124871 PHB 17q21.3 prohibitin LOC388400 17 similar to Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) NGFR 17q21.31 nerve growth factor receptor (TNFR superfamily, member 16) NXPH3 17q21.31 neurexophilin 3 SPOP 17q22 speckle-type POZ protein SLC35B1 17q21.3-q22 solute carrier family 35, member B1 LOC81558 17q21.33 C/EBP-induced protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1058 - 69 - DePuy (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina  specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • GGL domain
  • HOMOLOGY
    interspecies homolog to murine Gngt2
    Homologene
    FAMILY
  • G protein gamma family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a crucial role in cone phototransduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of heterotrimeric G-protein, cone transducin, comprising GNAT2, GNB3 and GNGT2 subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARRB1 (functions of ARRB1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signaling for NF-kappaB activation) (Yang 2009)
  • cell & other
    REGULATION
    activated by TH (Liu 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS