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FLASH GENE
Symbol WNT9B contributors: mct/npt - updated : 27-01-2014
HGNC name wingless-type MMTV integration site family, member 9B
HGNC id 12779
Location 17q21.32      Physical location : 44.928.967 - 44.954.437
Synonym name wingless-type MMTV integration site family, member 15
Synonym symbol(s) WNT14B, WNT15
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, head to head
text head to head with WNT3
STRUCTURE 25.47 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - BRCA1 BRCA1 - (WNT9B ,WNT3 ,D17S91 ) - D17S806 - qter
Authors Bergstein (97)
Physical map
CRHR1 17q12-q22 corticotropin releasing hormone receptor 1 IMP5 17q21.31 intramembrane protease 5 MAPT 17q21.11 microtubule-associated protein tau DKFZP727C091 LOC284054 17q21.32 similar to C-jun-amino-terminal kinase interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1) LOC124981 17q21.32 similar to dead end homolog 1; dead end protein LOC388392 17 similar to FALZ protein LOC201173 17q21.32 similar to KIAA0563 protein LOC51326 17q21.32 ARF protein NSF 17q21-q22 N-ethylmaleimide-sensitive factor WNT3 17q21.31 wingless-type MMTV integration site family, member 3 LOC388393 17 LOC388393 WNT9B 17q21 wingless-type MMTV integration site family, member 9B GOSR2 17q21 golgi SNAP receptor complex member 2 LOC388394 17 similar to RIKEN cDNA 2410012A13 LOC388395 17 similar to Hypothetical protein KIAA0563 LOC388396 17 similar to KIAA0563 protein LOC388397 17 LOC388397 CDC27 17q21.3 cell division cycle 27 MYL4 17q21.2 myosin, light polypeptide 4, alkali; atrial, embryonic ITGB3 17q21.31 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) FLJ40342 17q21.32 hypothetical protein FLJ40342 NPEPPS 17q21.2-q21.32 aminopeptidase puromycin sensitive KPNB1 17q21.32 karyopherin (importin) beta 1 ProSAPiP2 17q21.32 ProSAPiP2 protein TBX21 17q21.3 T-box 21 OSBPL7 17q21.2 oxysterol binding protein-like 7 MRPL10 17q21.32 mitochondrial ribosomal protein L10 MGC16309 17q21.32 hypothetical gene MGC16309 Ses2 17q21.32 secernin 2 SP6 17q21.3-q22 Sp6 transcription factor LOC388398 17 LOC388398 SP2 17q21.3-q22 Sp2 transcription factor PNPO 17q21.32 pyridoxine-5'-phosphate oxidase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1464 - 357 - 2001 1160499
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral lobeoccipital 
Urinarykidneytubulecollecting duct  
 ureter    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an N-linked glycosylation site
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (Wg) segment polarity gene
    homolog to murine mammary tumor virus integration site oncogene
    intraspecies homolog to WNT14
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • having a necessary role for the earliest events in the induction of the kidney tubules (Karner 2009)
  • regulates both phases of development, perhaps through a role in regulating cell orientation (Karner 2009)
  • plays a role in renal tubule morphogenesis and is necessary for the oriented cell divisions that occur in the postnatal kidney (Karner 2009)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
  • WNT9B/CTNNB1 signaling is active in the progenitors and is required for their renewal/proliferation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulatory link between WNT9B and FGF signaling during lip and upper jaw development
  • expression of WNT9B in SIX2-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nonsyndromic cleft lip with or without cleft palate (NSCLąP)
    Variant & Polymorphism SNP
  • SNP rs1530364 associated with to nonsyndromic cleft lip with or without cleft palate (pmids; 24437584)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryos completely lacking functional Wnt9b fail to form kidneys, resulting in death on postnatal day 1 (Wnt9b was required for proper establishment and/or maintenance of tubule diameter) (Karner 2009)
  • Wnt9b(-/-) mice show significantly retarded outgrowth of the nasal and maxillary processes due to reduced proliferation of mesenchymal cells