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FLASH GENE

Symbol

WNT9B

contributors: mct/npt - updated : 27-01-2014

HGNC name	wingless-type MMTV integration site family, member 9B
HGNC id	12779

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral lobe occipital   Urinary kidney tubule collecting duct       ureter

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	an N-linked glycosylation site

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to Drosophila wingless (Wg) segment polarity gene
	homolog to murine mammary tumor virus integration site oncogene

intraspecies

homolog to WNT14

Homologene

FAMILY

WNT family

CATEGORY

protooncogene , signaling

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	modulating cell fate and cell behavior during vertebrate development
	having a necessary role for the earliest events in the induction of the kidney tubules (Karner 2009)
	regulates both phases of development, perhaps through a role in regulating cell orientation (Karner 2009)
	plays a role in renal tubule morphogenesis and is necessary for the oriented cell divisions that occur in the postnatal kidney (Karner 2009)

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

WNT9B/CTNNB1 signaling is active in the progenitors and is required for their renewal/proliferation

a component

INTERACTION

DNA

RNA

small molecule

protein	regulatory link between WNT9B and FGF signaling during lip and upper jaw development
	expression of WNT9B in SIX2-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to nonsyndromic cleft lip with or without cleft palate (NSCL±P)

Variant & Polymorphism SNP	SNP rs1530364 associated with to nonsyndromic cleft lip with or without cleft palate (pmids; 24437584)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	embryos completely lacking functional Wnt9b fail to form kidneys, resulting in death on postnatal day 1 (Wnt9b was required for proper establishment and/or maintenance of tubule diameter) (Karner 2009)
	Wnt9b(-/-) mice show significantly retarded outgrowth of the nasal and maxillary processes due to reduced proliferation of mesenchymal cells