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FLASH GENE
Symbol WNT9B contributors: mct/npt - updated : 27-01-2014
HGNC name wingless-type MMTV integration site family, member 9B
HGNC id 12779
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility to nonsyndromic cleft lip with or without cleft palate (NSCLąP)
Variant & Polymorphism SNP
  • SNP rs1530364 associated with to nonsyndromic cleft lip with or without cleft palate (pmids; 24437584)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryos completely lacking functional Wnt9b fail to form kidneys, resulting in death on postnatal day 1 (Wnt9b was required for proper establishment and/or maintenance of tubule diameter) (Karner 2009)
  • Wnt9b(-/-) mice show significantly retarded outgrowth of the nasal and maxillary processes due to reduced proliferation of mesenchymal cells