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FLASH GENE
Symbol WNT9B contributors: mct/npt - updated : 27-01-2014
HGNC name wingless-type MMTV integration site family, member 9B
HGNC id 12779
Location 17q21.32      Physical location : 44.928.967 - 44.954.437
Synonym name wingless-type MMTV integration site family, member 15
Synonym symbol(s) WNT14B, WNT15
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, head to head
text head to head with WNT3
STRUCTURE 25.47 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - BRCA1 BRCA1 - (WNT9B ,WNT3 ,D17S91 ) - D17S806 - qter
Authors Bergstein (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1464 - 357 - 2001 1160499
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral lobeoccipital 
Urinarykidneytubulecollecting duct  
 ureter    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an N-linked glycosylation site
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (Wg) segment polarity gene
    homolog to murine mammary tumor virus integration site oncogene
    intraspecies homolog to WNT14
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • having a necessary role for the earliest events in the induction of the kidney tubules (Karner 2009)
  • regulates both phases of development, perhaps through a role in regulating cell orientation (Karner 2009)
  • plays a role in renal tubule morphogenesis and is necessary for the oriented cell divisions that occur in the postnatal kidney (Karner 2009)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
  • WNT9B/CTNNB1 signaling is active in the progenitors and is required for their renewal/proliferation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulatory link between WNT9B and FGF signaling during lip and upper jaw development
  • expression of WNT9B in SIX2-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nonsyndromic cleft lip with or without cleft palate (NSCLąP)
    Variant & Polymorphism SNP
  • SNP rs1530364 associated with to nonsyndromic cleft lip with or without cleft palate (pmids; 24437584)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryos completely lacking functional Wnt9b fail to form kidneys, resulting in death on postnatal day 1 (Wnt9b was required for proper establishment and/or maintenance of tubule diameter) (Karner 2009)
  • Wnt9b(-/-) mice show significantly retarded outgrowth of the nasal and maxillary processes due to reduced proliferation of mesenchymal cells