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FLASH GENE
Symbol WNT9B contributors: mct/npt - updated : 27-01-2014
HGNC name wingless-type MMTV integration site family, member 9B
HGNC id 12779
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an N-linked glycosylation site
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (Wg) segment polarity gene
    homolog to murine mammary tumor virus integration site oncogene
    intraspecies homolog to WNT14
    Homologene
    FAMILY
  • WNT family
    • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • having a necessary role for the earliest events in the induction of the kidney tubules (Karner 2009)
  • regulates both phases of development, perhaps through a role in regulating cell orientation (Karner 2009)
  • plays a role in renal tubule morphogenesis and is necessary for the oriented cell divisions that occur in the postnatal kidney (Karner 2009)
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
  • WNT9B/CTNNB1 signaling is active in the progenitors and is required for their renewal/proliferation
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulatory link between WNT9B and FGF signaling during lip and upper jaw development
  • expression of WNT9B in SIX2-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nonsyndromic cleft lip with or without cleft palate (NSCLąP)
    Variant & Polymorphism SNP
  • SNP rs1530364 associated with to nonsyndromic cleft lip with or without cleft palate (pmids; 24437584)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryos completely lacking functional Wnt9b fail to form kidneys, resulting in death on postnatal day 1 (Wnt9b was required for proper establishment and/or maintenance of tubule diameter) (Karner 2009)
  • Wnt9b(-/-) mice show significantly retarded outgrowth of the nasal and maxillary processes due to reduced proliferation of mesenchymal cells