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FLASH GENE

Symbol

WDFY3

contributors: mct - updated : 29-04-2011

HGNC name	WD repeat and FYVE domain containing 3
HGNC id	20751

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q21.23      Physical location : 85.590.696 - 85.887.544
Genatlas name	related to C elegans Cos T23B5
Synonym name	autophagy-linked FYVE protein
Synonym symbol(s)	ALFY, ZFYVE25, KIAA0993, MGC16461

DNA

TYPE	functioning gene
STRUCTURE	296.85 kb     68 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014991 68 - 14329 - 3526 - 2010 20417604 I2 - - 3498 - 795 - Nagase I3 - - 4650 - 281 - Nagase

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           spinal cord         Reproductive female system ovary         male system testis       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)

cells

System Cell Pubmed Species Stage Rna symbol Skeleton osteoclast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

WD repeats and an FYVE domain

HOMOLOGY

interspecies

homolog to C.elegans cosmid T23B5

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nuclear envelope
text	not found on endosomes but instead localizes mainly to the nuclear envelope

basic FUNCTION	might target cytosolic protein aggregates for autophagic degradation
	as well as SQSTM1, is required for formation and autophagic degradation of cytoplasmic ubiquitin-positive inclusions
	required for autophagic degradation of SQSTM1-associated ubiquitinated proteins
	inclusions phosphatidylinositol 3-phosphate-binding protein, central to the selective elimination of aggregated proteins (
	may plays a key role in selective macroautophagy by bridging cargo to the molecular machinery that builds autophagosomes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with SQSTM1 (is required to recruit the large phosphoinositide-binding protein WDFY3 to cytoplasmic SQSTM1 bodies generated upon AA starvation or puromycin-treatment)
	functional interaction between SQSTM1 and WDFY3 in osteoclasts under conditions of cell stress (

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS