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FLASH GENE
Symbol WDFY3 contributors: mct - updated : 29-04-2011
HGNC name WD repeat and FYVE domain containing 3
HGNC id 20751
DNA
TYPE functioning gene
STRUCTURE 296.85 kb     68 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC345258 4q21.3 similar to bridging integrator 2; bridging integrator-2; breast cancer associated protein BRAP1 HNRPD 4q21.1-q21.2 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) LOC391672 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) HNRPDL 4q13-q21 heterogeneous nuclear ribonucleoprotein D-like MASA 4q21.3 E-1 enzyme LOC391673 4 similar to protein-tyrosine phosphatase SCD4 4q21.3 stearoyl-CoA desaturase 4 KIAA0905 4q21.3 stearoyl-CoA desaturase 4 THAP9 4q21.3 THAP domain containing 9 DKFZp686L1814 4q21.3 hypothetical protein DKFZp686L1814 COPS4 4q21.21-q21.23 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) PLAC8 4q21.22 placenta-specific 8 LOC391674 4 similar to Aminomethyltransferase, mitochondrial precursor (Glycine cleavage system T protein) (GCVT) CL640 4q21.3 hypothetical protein CL640 HPSE 4q21.3 heparanase HEL308 4q21.3 DNA helicase HEL308 MRPS18C 4q21.3 mitochondrial ribosomal protein S18C FLJ13614 4q21.21-q21.23 hypothetical protein FLJ13614 MGC11324 4q21.3 hypothetical protein MGC11324 LOC152845 4q21.3 similar to product similar to X.laevis finger protein. NKX6-1 4q21.2-q22 NK6 transcription factor related, locus 1 (Drosophila) CDS1 4q21 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 WDFY3 4q21.23 WD repeat and FYVE domain containing 3 LOC391675 4 LOC391675 DKFZP564B1162 4q22.1 hypothetical protein DKFZp564B1162 MAPK10 4q21-q22 mitogen-activated protein kinase 10 PTPN13 4q21.3 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) SOAT 4q22.1 sodium-dependent organic anion transporter MGC26744 4q22.1 hypothetical protein MGC26744 LOC260422 4q21.3 actin related protein 2/3 complex subunit 1A pseudogene LOC389210 4 similar to hypothetical protein LOC391676 4 similar to Synaptic glycoprotein SC2 MLLT2 4q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 KLHL8 4q22.1 kelch-like 8 (Drosophila) GAPDL4 4pter-p16.2 glyceraldehyde-3-phosphate dehydrogenase-like 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
68 - 14329 - 3526 - 2010 20417604
- - 3498 - 795 - Nagase
- - 4650 - 281 - Nagase
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 spinal cord    
Reproductivefemale systemovary   
 male systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoclast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
WD repeats and an FYVE domain
HOMOLOGY
interspecies homolog to C.elegans cosmid T23B5
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,nuclear envelope
text
  • not found on endosomes but instead localizes mainly to the nuclear envelope
  • basic FUNCTION
  • might target cytosolic protein aggregates for autophagic degradation
  • as well as SQSTM1, is required for formation and autophagic degradation of cytoplasmic ubiquitin-positive inclusions
  • required for autophagic degradation of SQSTM1-associated ubiquitinated proteins
  • inclusions phosphatidylinositol 3-phosphate-binding protein, central to the selective elimination of aggregated proteins (
  • may plays a key role in selective macroautophagy by bridging cargo to the molecular machinery that builds autophagosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SQSTM1 (is required to recruit the large phosphoinositide-binding protein WDFY3 to cytoplasmic SQSTM1 bodies generated upon AA starvation or puromycin-treatment)
  • functional interaction between SQSTM1 and WDFY3 in osteoclasts under conditions of cell stress (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS