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FLASH GENE
Symbol WDFY3 contributors: mct - updated : 29-04-2011
HGNC name WD repeat and FYVE domain containing 3
HGNC id 20751
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
WD repeats and an FYVE domain
HOMOLOGY
interspecies homolog to C.elegans cosmid T23B5
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,nuclear envelope
text
  • not found on endosomes but instead localizes mainly to the nuclear envelope
  • basic FUNCTION
  • might target cytosolic protein aggregates for autophagic degradation
  • as well as SQSTM1, is required for formation and autophagic degradation of cytoplasmic ubiquitin-positive inclusions
  • required for autophagic degradation of SQSTM1-associated ubiquitinated proteins
  • inclusions phosphatidylinositol 3-phosphate-binding protein, central to the selective elimination of aggregated proteins (
  • may plays a key role in selective macroautophagy by bridging cargo to the molecular machinery that builds autophagosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SQSTM1 (is required to recruit the large phosphoinositide-binding protein WDFY3 to cytoplasmic SQSTM1 bodies generated upon AA starvation or puromycin-treatment)
  • functional interaction between SQSTM1 and WDFY3 in osteoclasts under conditions of cell stress (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS