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FLASH GENE
Symbol WDFY3 contributors: mct - updated : 29-04-2011
HGNC name WD repeat and FYVE domain containing 3
HGNC id 20751
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
68 - 14329 - 3526 - 2010 20417604
- - 3498 - 795 - Nagase
- - 4650 - 281 - Nagase
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 spinal cord    
Reproductivefemale systemovary   
 male systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoclast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
WD repeats and an FYVE domain
HOMOLOGY
interspecies homolog to C.elegans cosmid T23B5
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,nuclear envelope
text
  • not found on endosomes but instead localizes mainly to the nuclear envelope
  • basic FUNCTION
  • might target cytosolic protein aggregates for autophagic degradation
  • as well as SQSTM1, is required for formation and autophagic degradation of cytoplasmic ubiquitin-positive inclusions
  • required for autophagic degradation of SQSTM1-associated ubiquitinated proteins
  • inclusions phosphatidylinositol 3-phosphate-binding protein, central to the selective elimination of aggregated proteins (
  • may plays a key role in selective macroautophagy by bridging cargo to the molecular machinery that builds autophagosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SQSTM1 (is required to recruit the large phosphoinositide-binding protein WDFY3 to cytoplasmic SQSTM1 bodies generated upon AA starvation or puromycin-treatment)
  • functional interaction between SQSTM1 and WDFY3 in osteoclasts under conditions of cell stress (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS