Citations for
1WAS, WASF1
WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility.
Fritz-Laylin LK, Lord SJ, Mullins RD.
J Cell Biol 216(6):1673-1688. doi: 10.1083/jcb.201701074. Epub 2017 May 4. 2017
2WAS, WASL
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.
Jain N, Thanabalu T.
Sci Rep 5:15031. doi: 10.1038/srep15031. 2015
3PSTPIP1, WAS
The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.
Starnes TW, Bennin DA, Bing X, Eickhoff JC, Grahf DC, Bellak JM, Seroogy CM, Ferguson PJ, Huttenlocher A.
Blood 123(17):2703-14. doi: 10.1182/blood-2013-07-516948. Epub 2014 Jan 13. 2014
4WAS, WASF2
WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.
Pauker MH, Reicher B, Joseph N, Wortzel I, Jakubowicz S, Noy E, Perl O, Barda-Saad M.
J Biol Chem 289(50):34503-19. doi: 10.1074/jbc.M114.591685. Epub 2014 Oct 23. 2014
5WAS, XLN, XLT
X-linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis.
Jain N, Tan JH, Feng S, George B, Thanabalu T.
J Biomed Sci 21:91. doi: 10.1186/s12929-014-0091-1. 2014
6WAS, WASP
Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization.
Sadhukhan S, Sarkar K, Taylor M, Candotti F, Vyas YM.
J Immunol 193(1):150-60. doi: 10.4049/jimmunol.1302923. Epub 2014 May 28. 2014
7WAS, WASP
Wiskott-Aldrich Syndrome causing mutation, Pro373Ser restricts conformational changes essential for WASP activity in T-cells.
Jain N, George B, Thanabalu T.
Biochim Biophys Acta 1842(4):623-34. doi: 10.1016/j.bbadis.2014.01.006. Epub 2014 Jan 15. 2014
8BAIAP2, CDC42, TGFBR3, WAS
The Type III TGF-β receptor regulates filopodia formation via a Cdc42-mediated IRSP53: NWASP interaction in epithelial cells.
Oh SY, Knelson EH, Blobe GC, Mythreye K.
Biochem J iochem J. 2013 Jun 10. [Epub ahead of print] 2013
9WAS
Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1.
Kim H, Falet H, Hoffmeister KM, Hartwig JH.
J Biol Chem 288(48):34352-63. doi: 10.1074/jbc.M113.459750. Epub 2013 Oct 16. 2013
10WAS
Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1.
Lafouresse F, Cotta-de-Almeida V, Malet-Engra G, Galy A, Valitutti S, Dupré L.
Immunology 137(2):183-96. doi: 10.1111/j.1365-2567.2012.03620.x. 2012
11WAS
Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics.
Reicher B, Joseph N, David A, Pauker MH, Perl O, Barda-Saad M.
Mol Cell Biol 32(15):3153-63. doi: 10.1128/MCB.00161-12. Epub 2012 Jun 4. 2012
12WAS, WIPF1
WIP: WASP-interacting proteins at invadopodia and podosomes.
García E, Jones GE, Machesky LM, Antón IM.
Eur J Cell Biol 91(11-12):869-77. doi: 10.1016/j.ejcb.2012.06.002. Epub 2012 Jul 21. Review. 2012
13ITGAM, WAS
Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules.
Kumar S, Xu J, Perkins C, Guo F, Snapper S, Finkelman FD, Zheng Y, Filippi MD.
Blood 120(17):3563-74. doi: 10.1182/blood-2012-04-426981. Epub 2012 Aug 29. 2012
14WAS
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Bouma G, Mendoza-Naranjo A, Blundell MP, de Falco E, Parsley KL, Burns SO, Thrasher AJ.
Blood 118(9):2492-501. doi: 10.1182/blood-2011-03-340265. Epub 2011 Jun 20. 2011
15WAS, WASF1, WASF2, WASF3
Relative actin nucleation promotion efficiency by WASP and WAVE proteins in endothelial cells.
Kang H, Wang J, Longley SJ, Tang JX, Shaw SK.
Biochem Biophys Res Commun 400(4):661-6. Epub 2010 Sep 9. 2010
16WAS, WASP
A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes.
Burns SO, Killock DJ, Moulding DA, Metelo J, Nunes J, Taylor RR, Forge A, Thrasher AJ, Ivetic A.
Blood 115(26):5355-65. doi: 10.1182/blood-2009-08-236174. Epub 2010 Mar 30. 2010
17DNM2, FNBP1, WAS, WIPF1
FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages.
Tsuboi S, Takada H, Hara T, Mochizuki N, Funyu T, Saitoh H, Terayama Y, Yamaya K, Ohyama C, Nonoyama S, Ochs HD.
J Biol Chem 284(13):8548-56. Epub 2009 Jan 20. 2009
18ROBO1, ROBO4, WAS
Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors.
Sheldon H, Andre M, Legg JA, Heal P, Herbert JM, Sainson R, Sharma AS, Kitajewski JK, Heath VL, Bicknell R.
FASEB J 23(2):513-22. Epub 2008 Oct 23. 2009
19WAS, WIPF1
WIP is critical for T cell responsiveness to IL-2.
Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi MK, Hartwig J, Geha RS.
Proc Natl Acad Sci U S A 106(18):7519-24. Epub 2009 Apr 9. 2009
20SNX33, WAS
Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein.
Zhang J, Zhang X, Guo Y, Xu L, Pei D.
J Biol Chem 284(32):21659-69. Epub 2009 Jun 1.PMID: 19487689 2009
21WAS
Phosphorylation of WASp is a key regulator of activity and stability in vivo.
Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ.
Proc Natl Acad Sci U S A 106(37):15738-43. Epub 2009 Sep 1.PMID: 19805221 2009
22WAS
Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome.
Lutskiy MI, Park JY, Remold SK, Remold-O'Donnell E.
PLoS One 3(10):e3444. Epub 2008 Oct 20. 2008
23WAS, WASF1
The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
Takenawa T, Suetsugu S.
Nat Rev Mol Cell Biol 8(1):37-48. 2007
24WAS, WIPF1
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
de la Fuente MA, Sasahara Y, Calamito M, Anton IM, Elkhal A, Gallego MD, Suresh K, Siminovitch K, Ochs HD, Anderson KC, Rosen FS, Geha RS, Ramesh N.
Proc Natl Acad Sci U S A 104(3):926-31. Epub 2007 Jan 9. 2007
25WAS, WASL
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.
Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.
Proc Natl Acad Sci U S A 104(39):15424-9. Epub 2007 Sep 18. 2007
26WAS
A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient.
Du W, Kumaki S, Uchiyama T, Yachie A, Yeng Looi C, Kawai S, Minegishi M, Ramesh N, Geha RS, Sasahara Y, Tsuchiya S.
Hum Mutat 27(4):370-5. 2006
27WAS, WASP, XLN, XLT
The Wiskott-Aldrich syndrome.
Ochs HD, Thrasher AJ.
J Allergy Clin Immunol 117(4):725-38; quiz 739. Review. 2006
28WAS
Characterization of an aldolase-binding site in the Wiskott-Aldrich syndrome protein.
Buscaglia CA, Penesetti D, Tao M, Nussenzweig V.
J Biol Chem 281(3):1324-31. Epub 2005 Nov 8. 2006
29WAS, WASF1, WIPF1, VASP, SPIRE1, SPIRE2
Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.
Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R.
Proc Natl Acad Sci U S A 102(46):16644-9. Epub 2005 Nov 7. 2005
30WAS, WASP, XLT, XLN
Genotype-proteotype linkage in the Wiskott-Aldrich syndrome.
Lutskiy MI, Rosen FS, Remold-O'Donnell E.
J Immunol 175(2):1329-36. 2005
31WAS, WASP, WIPF1
Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling.
Kim MK, Kim ES, Kim DS, Choi IH, Moon T, Yoon CN, Shin JS.
Biochim Biophys Acta 1690(2):134-40. 2004
32WAS, WASP, XLT, XLN
Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation.
Jin Y, Mazza C, Christie JR, Giliani S, Fiorini M, Mella P, Gandellini F, Stewart DM, Zhu Q, Nelson DL, Notarangelo LD, Ochs HD.
Blood 104(13):4010-9. Epub 2004 Jul 29. 2004
33WAS, PTPN12
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch KA.
J Exp Med 199(1):99-112. 2004
34WAS, WASP
Identification and characterization of a novel splice-site mutation in a patient with Wiskott-Aldrich syndrome.
Andreu N, Carreras C, Prieto F, Estivill X, Volpini V, Fillat C.
J Hum Genet 48(11):590-3. Epub 2003 Oct 18. 2003
35WAS
Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.
Wada T, Schurman SH, Otsu M, Garabedian EK, Ochs HD, Nelson DL, Candotti F.
Proc Natl Acad Sci U S A 98(15):8697-702. 2001
36CDC42, ITSN2, WAS
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA.
J Exp Med 194(12):1777-87. 2001
37CDC42, RAC1, WAS
Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
Westerberg L, Greicius G, Snapper SB, Aspenstrom P, Severinson E.
Blood 98(4):1086-94. 2001
38SUV39H1, WAS
Gene regulation of Wiskott-Aldrich syndrome protein and the human homolog of the Drosophila Su(var)3-9: WASP and SUV39H1, two adjacent genes at Xp11.23.
Hagemann TL, Mares D, Kwan S.
Biochim Biophys Acta 1493(3):368-72. 2000
39WAS
Structural basis of Wiskott-Aldrich syndrome causing mutations in the WH1 domain.
Rong SB, Vihinen M.
J Mol Med 78(9):530-7. 2000
40 WAS,WASP, XLT
Mutation spectrum in patients with Wiskott-Aldrich syndrome and X-linkedthrombocytopenia : identification of twelve different mutations in the WASP gene.
Schwartz M, et al.
Thromb Haemost 75 : 546-550. 1996
41WAS, WASP, XLT
Isolated X-linked thrombocytopenia in two unrelated families is associated with point mutations in the Wiskott-Aldrich syndrome protein gene.
de Saint Basile G, et al.
J Pediatr 129 : 56-62. 1996
42WAS, WASP, XLT
The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene.
Zhu Q, et al.
Blood 86 : 3797-3804. 1995
43WAS, WASP,XLT
X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene.
Villa A, et al.
Nat Genet 9 : 414-417. 1995
44WAS, WASP, XLT
Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region.
Cremin SM, et al.
Hum Genet 92 : 250-253. 1993