| 1 | WAS, WASF1
|
| WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility.
|
| Fritz-Laylin LK, Lord SJ, Mullins RD.
|
| J Cell Biol 216(6):1673-1688. doi: 10.1083/jcb.201701074. Epub 2017 May 4.
2017
|
| 2 | WAS, WASL
|
| Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.
|
| Jain N, Thanabalu T.
|
| Sci Rep 5:15031. doi: 10.1038/srep15031.
2015
|
| 3 | PSTPIP1, WAS
|
| The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.
|
| Starnes TW, Bennin DA, Bing X, Eickhoff JC, Grahf DC, Bellak JM, Seroogy CM, Ferguson PJ, Huttenlocher A.
|
| Blood 123(17):2703-14. doi: 10.1182/blood-2013-07-516948. Epub 2014 Jan 13.
2014
|
| 4 | WAS, WASF2
|
| WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.
|
| Pauker MH, Reicher B, Joseph N, Wortzel I, Jakubowicz S, Noy E, Perl O, Barda-Saad M.
|
| J Biol Chem 289(50):34503-19. doi: 10.1074/jbc.M114.591685. Epub 2014 Oct 23.
2014
|
| 5 | WAS, XLN, XLT
|
| X-linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis.
|
| Jain N, Tan JH, Feng S, George B, Thanabalu T.
|
| J Biomed Sci 21:91. doi: 10.1186/s12929-014-0091-1.
2014
|
| 6 | WAS, WASP
|
| Nuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization.
|
| Sadhukhan S, Sarkar K, Taylor M, Candotti F, Vyas YM.
|
| J Immunol 193(1):150-60. doi: 10.4049/jimmunol.1302923. Epub 2014 May 28.
2014
|
| 7 | WAS, WASP
|
| Wiskott-Aldrich Syndrome causing mutation, Pro373Ser restricts conformational changes essential for WASP activity in T-cells.
|
| Jain N, George B, Thanabalu T.
|
| Biochim Biophys Acta 1842(4):623-34. doi: 10.1016/j.bbadis.2014.01.006. Epub 2014 Jan 15.
2014
|
| 8 | BAIAP2, CDC42, TGFBR3, WAS
|
| The Type III TGF-β receptor regulates filopodia formation via a Cdc42-mediated IRSP53: NWASP interaction in epithelial cells.
|
| Oh SY, Knelson EH, Blobe GC, Mythreye K.
|
| Biochem J iochem J. 2013 Jun 10. [Epub ahead of print]
2013
|
| 9 | WAS
|
| Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1.
|
| Kim H, Falet H, Hoffmeister KM, Hartwig JH.
|
| J Biol Chem 288(48):34352-63. doi: 10.1074/jbc.M113.459750. Epub 2013 Oct 16.
2013
|
| 10 | WAS
|
| Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1.
|
| Lafouresse F, Cotta-de-Almeida V, Malet-Engra G, Galy A, Valitutti S, Dupré L.
|
| Immunology 137(2):183-96. doi: 10.1111/j.1365-2567.2012.03620.x.
2012
|
| 11 | WAS
|
| Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics.
|
| Reicher B, Joseph N, David A, Pauker MH, Perl O, Barda-Saad M.
|
| Mol Cell Biol 32(15):3153-63. doi: 10.1128/MCB.00161-12. Epub 2012 Jun 4.
2012
|
| 12 | WAS, WIPF1
|
| WIP: WASP-interacting proteins at invadopodia and podosomes.
|
| García E, Jones GE, Machesky LM, Antón IM.
|
| Eur J Cell Biol 91(11-12):869-77. doi: 10.1016/j.ejcb.2012.06.002. Epub 2012 Jul 21. Review.
2012
|
| 13 | ITGAM, WAS
|
| Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules.
|
| Kumar S, Xu J, Perkins C, Guo F, Snapper S, Finkelman FD, Zheng Y, Filippi MD.
|
| Blood 120(17):3563-74. doi: 10.1182/blood-2012-04-426981. Epub 2012 Aug 29.
2012
|
| 14 | WAS
|
| Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
|
| Bouma G, Mendoza-Naranjo A, Blundell MP, de Falco E, Parsley KL, Burns SO, Thrasher AJ.
|
| Blood 118(9):2492-501. doi: 10.1182/blood-2011-03-340265. Epub 2011 Jun 20.
2011
|
| 15 | WAS, WASF1, WASF2, WASF3
|
| Relative actin nucleation promotion efficiency by WASP and WAVE proteins in endothelial cells.
|
| Kang H, Wang J, Longley SJ, Tang JX, Shaw SK.
|
| Biochem Biophys Res Commun 400(4):661-6. Epub 2010 Sep 9.
2010
|
| 16 | WAS, WASP
|
| A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes.
|
| Burns SO, Killock DJ, Moulding DA, Metelo J, Nunes J, Taylor RR, Forge A, Thrasher AJ, Ivetic A.
|
| Blood 115(26):5355-65. doi: 10.1182/blood-2009-08-236174. Epub 2010 Mar 30.
2010
|
| 17 | DNM2, FNBP1, WAS, WIPF1
|
| FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages.
|
| Tsuboi S, Takada H, Hara T, Mochizuki N, Funyu T, Saitoh H, Terayama Y, Yamaya K, Ohyama C, Nonoyama S, Ochs HD.
|
| J Biol Chem 284(13):8548-56. Epub 2009 Jan 20.
2009
|
| 18 | ROBO1, ROBO4, WAS
|
| Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors.
|
| Sheldon H, Andre M, Legg JA, Heal P, Herbert JM, Sainson R, Sharma AS, Kitajewski JK, Heath VL, Bicknell R.
|
| FASEB J 23(2):513-22. Epub 2008 Oct 23.
2009
|
| 19 | WAS, WIPF1
|
| WIP is critical for T cell responsiveness to IL-2.
|
| Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi MK, Hartwig J, Geha RS.
|
| Proc Natl Acad Sci U S A 106(18):7519-24. Epub 2009 Apr 9.
2009
|
| 20 | SNX33, WAS
|
| Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein.
|
| Zhang J, Zhang X, Guo Y, Xu L, Pei D.
|
| J Biol Chem 284(32):21659-69. Epub 2009 Jun 1.PMID: 19487689 2009
|
| 21 | WAS
|
| Phosphorylation of WASp is a key regulator of activity and stability in vivo.
|
| Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ.
|
| Proc Natl Acad Sci U S A 106(37):15738-43. Epub 2009 Sep 1.PMID: 19805221 2009
|
| 22 | WAS
|
| Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome.
|
| Lutskiy MI, Park JY, Remold SK, Remold-O'Donnell E.
|
| PLoS One 3(10):e3444. Epub 2008 Oct 20.
2008
|
| 23 | WAS, WASF1
|
| The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
|
| Takenawa T, Suetsugu S.
|
| Nat Rev Mol Cell Biol 8(1):37-48. 2007
|
| 24 | WAS, WIPF1
|
| WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).
|
| de la Fuente MA, Sasahara Y, Calamito M, Anton IM, Elkhal A, Gallego MD, Suresh K, Siminovitch K, Ochs HD, Anderson KC, Rosen FS, Geha RS, Ramesh N.
|
| Proc Natl Acad Sci U S A 104(3):926-31. Epub 2007 Jan 9. 2007
|
| 25 | WAS, WASL
|
| Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.
|
| Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.
|
| Proc Natl Acad Sci U S A 104(39):15424-9. Epub 2007 Sep 18. 2007
|
| 26 | WAS
|
| A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient.
|
| Du W, Kumaki S, Uchiyama T, Yachie A, Yeng Looi C, Kawai S, Minegishi M, Ramesh N, Geha RS, Sasahara Y, Tsuchiya S.
|
| Hum Mutat 27(4):370-5. 2006
|
| 27 | WAS, WASP, XLN, XLT
|
| The Wiskott-Aldrich syndrome.
|
| Ochs HD, Thrasher AJ.
|
| J Allergy Clin Immunol 117(4):725-38; quiz 739. Review. 2006
|
| 28 | WAS
|
| Characterization of an aldolase-binding site in the Wiskott-Aldrich syndrome protein.
|
| Buscaglia CA, Penesetti D, Tao M, Nussenzweig V.
|
| J Biol Chem 281(3):1324-31. Epub 2005 Nov 8. 2006
|
| 29 | WAS, WASF1, WIPF1, VASP, SPIRE1, SPIRE2
|
| Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.
|
| Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R.
|
| Proc Natl Acad Sci U S A 102(46):16644-9. Epub 2005 Nov 7. 2005
|
| 30 | WAS, WASP, XLT, XLN
|
| Genotype-proteotype linkage in the Wiskott-Aldrich syndrome.
|
| Lutskiy MI, Rosen FS, Remold-O'Donnell E.
|
| J Immunol 175(2):1329-36. 2005
|
| 31 | WAS, WASP, WIPF1
|
| Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling.
|
| Kim MK, Kim ES, Kim DS, Choi IH, Moon T, Yoon CN, Shin JS.
|
| Biochim Biophys Acta 1690(2):134-40. 2004
|
| 32 | WAS, WASP, XLT, XLN
|
| Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation.
|
| Jin Y, Mazza C, Christie JR, Giliani S, Fiorini M, Mella P, Gandellini F, Stewart DM, Zhu Q, Nelson DL, Notarangelo LD, Ochs HD.
|
| Blood 104(13):4010-9. Epub 2004 Jul 29. 2004
|
| 33 | WAS, PTPN12
|
| Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
|
| Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch KA.
|
| J Exp Med 199(1):99-112. 2004
|
| 34 | WAS, WASP
|
| Identification and characterization of a novel splice-site mutation in a patient with Wiskott-Aldrich syndrome.
|
| Andreu N, Carreras C, Prieto F, Estivill X, Volpini V, Fillat C.
|
| J Hum Genet 48(11):590-3. Epub 2003 Oct 18. 2003
|
| 35 | WAS
|
| Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.
|
| Wada T, Schurman SH, Otsu M, Garabedian EK, Ochs HD, Nelson DL, Candotti F.
|
| Proc Natl Acad Sci U S A 98(15):8697-702. 2001
|
| 36 | CDC42, ITSN2, WAS
|
| The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
|
| McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA.
|
| J Exp Med 194(12):1777-87. 2001
|
| 37 | CDC42, RAC1, WAS
|
| Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
|
| Westerberg L, Greicius G, Snapper SB, Aspenstrom P, Severinson E.
|
| Blood 98(4):1086-94. 2001
|
| 38 | SUV39H1, WAS
|
| Gene regulation of Wiskott-Aldrich syndrome protein and the human homolog of the Drosophila Su(var)3-9: WASP and SUV39H1, two adjacent genes at Xp11.23.
|
| Hagemann TL, Mares D, Kwan S.
|
| Biochim Biophys Acta 1493(3):368-72. 2000
|
| 39 | WAS
|
| Structural basis of Wiskott-Aldrich syndrome causing mutations in the WH1 domain.
|
| Rong SB, Vihinen M.
|
| J Mol Med 78(9):530-7. 2000
|
| 40 | WAS,WASP, XLT
|
| Mutation spectrum in patients with Wiskott-Aldrich syndrome and X-linkedthrombocytopenia : identification of twelve different mutations in the WASP gene.
|
| Schwartz M, et al.
|
| Thromb Haemost 75 : 546-550. 1996
|
| 41 | WAS, WASP, XLT
|
| Isolated X-linked thrombocytopenia in two unrelated families is associated with point mutations in the Wiskott-Aldrich syndrome protein gene.
|
| de Saint Basile G, et al.
|
| J Pediatr 129 : 56-62. 1996
|
| 42 | WAS, WASP, XLT
|
| The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene.
|
| Zhu Q, et al.
|
| Blood 86 : 3797-3804. 1995
|
| 43 | WAS, WASP,XLT
|
| X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene.
|
| Villa A, et al.
|
| Nat Genet 9 : 414-417. 1995
|
| 44 | WAS, WASP, XLT
|
| Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region.
|
| Cremin SM, et al.
|
| Hum Genet 92 : 250-253. 1993
|