protein
| directly interacts with Sp1, suggesting that formation of a TP73-Sp1 complex is the underlying mechanism for TP73-triggered inhibition of TERT expression |
|
interacting with SHISA5 (induces ER stress via the direct transactivation of Scotin) |
|
interacting with ZNF143 |
|
interacting with HCK (HCK-SH3 domain-mediated interactions play an important role in the inhibition of TP73-dependent transcriptional activation of a target gene, NLRC4, as well as apoptosis) |
|
interact directly with several partners of the SAC, spindle assembly checkpoint, complex (BUB1, BUB3, and BUB1B)(involved in SAC protein localization and activities) |
|
role for MSH5 in DNA damage response involving ABL and TP73, suggesting that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments |
|
interacts with CGTHBA (can modulate differentially the specific activities of selected TP73 isoforms) |
|
TP73 is a direct regulator for FOXJ1, a transcription factor important for the transactivation of genes encoding proteins involved in multiciliated cells (MCCs) differentiation |
|
TP73 binds to CASP8AP2 and is part of the complex that regulates histone gene transcription |
|
ubiquitination of TP73 mediated by RCHY1 represents an important pathway for controlling the suppressive function of TP73 |
|
RBM38 is a target of TP73, the mutual regulation between TP73 and RBM38 constitutes a novel feed-forward loop, which might be explored as a target for tumors without a functional TP53 |
|
important role of deregulated E2F in activation of the TP73 gene, a component of major intrinsic tumor suppressor pathways |
|
RANBP9 and TP73 have cooperative roles in inducing cell death, and the RANBP9/TP73 complex is implicated in mitochondria-mediated apoptosis in addition to its role in enhancing APP generation |
|
HDAC1 is a key regulator of TP73 protein stability |
|
TRIM32, a new direct TP73 transcriptional target in the context of neural progenitor cells, is differentially regulated by TP73 |
|
TP73 regulates GLS2 during retinoic acid-induced terminal neuronal differentiation of neuroblastoma cells |
|
WWP2, an E3 ligase, is a novel TP73-associated protein that ubiquitinates and degrades TP73 |
|
functional E3 ligase complex controlled by PPM1G that differentially regulates cellular TP73 and deltaNp73 |
|
RPL11 and RPL5 activate TP73 by overcoming MDM2 inhibition |
|
TP73 directly activates the key regulators FOXJ1, RFX2, RFX3 |
|
TP73 acts upstream of FOXJ1 and downstream of MCIDAS |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in bladder carcinoma | tumoral
|  
| deletion
|  
|  
|
in neuroblastoma in advanced stage | tumoral
|  
| amplification
|  
|  
|
in neuroblastoma,primary sqamous, primary sqamous cell carcinoma of the lung, head and neck cancer cell line | tumoral
|  
| LOH
|  
|  
|
in hepatocellular carcinoma | tumoral
|  
|  
|  
| loss of function
|
by abnormal methylation or LOH in non-Hodgkin lymphoma | tumoral
|  
|  
| --low
|  
|
correlates with increases of SAC protein expression in patients with lung cancer | tumoral
|  
|  
| --low
| gain of function
|
loss of TAp73 or deltaNp73 up-regulation activates the angiogenic switch that stimulates tumor growth and progression | tumoral
|  
|  
| --low
|  
|
TP73 methylation is common in patients with myelodysplastic syndromes and is associated with poor prognosis | tumoral
|  
|  
| --over
|  
|
in cervical cancer tissues and cells | |