Citations for
1FOXJ1, RFX2, RFX3, TP73
TAp73 is a central transcriptional regulator of airway multiciliogenesis.
Nemajerova A, Kramer D, Siller SS, Herr C, Shomroni O, Pena T, Gallinas Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll UM, Lizé M.
Genes Dev 30(11):1300-12. doi: 10.1101/gad.279836.116. 2016
2FOXJ1, TP73
p73 and FoxJ1: Programming Multiciliated Epithelia.
Jackson PK, Attardi LD.
Trends Cell Biol 26(4):239-40. doi: 10.1016/j.tcb.2016.03.001. 2016
3RPL11, RPL5, TP73
Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.
Zhou X, Hao Q, Zhang Q, Liao JM, Ke JW, Liao P, Cao B, Lu H.
Cell Death Differ 22(5):755-66. doi: 10.1038/cdd.2014.167. Epub 2014 Oct 10. 2015
4TP73
TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity.
Stantic M, Sakil HA, Zirath H, Fang T, Sanz G, Fernandez-Woodbridge A, Marin A, Susanto E, Mak TW, Arsenian Henriksson M, Wilhelm MT.
Proc Natl Acad Sci U S A 112(1):220-5. doi: 10.1073/pnas.1421697112. Epub 2014 Dec 22. 2015
5TP73
The role of the TP73 gene and its transcripts in neuro-oncology.
Jancalek R.
Br J Neurosurg 28(5):598-605. doi: 10.3109/02688697.2014.908162. Epub 2014 Apr 17. 2014
6TP73
TP73, an under-appreciated player in non-Hodgkin lymphoma pathogenesis and management.
Hassan HM, Dave BJ, Singh RK.
Curr Mol Med 14(4):432-9. Review. 2014
7TP73
Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma.
Hassan HM, Varney ML, Jain S, Weisenburger DD, Singh RK, Dave BJ.
Leuk Lymphoma 55(12):2924-31. doi: 10.3109/10428194.2014.900759. Epub 2014 May 6. 2014
8PPM1G, TP73, WWP1, WWP2
WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.
Chaudhary N, Maddika S.
Mol Cell Biol 34(19):3754-64. doi: 10.1128/MCB.00101-14. Epub 2014 Jul 28. 2014
9TP73
Structural dissection of the C-terminal sterile alpha motif (SAM) of human p73.
Neira JL.
Arch Biochem Biophys 558:133-42. doi: 10.1016/j.abb.2014.07.005. Epub 2014 Jul 14. 2014
10TP53, TP73
AMPK couples p73 with p53 in cell fate decision.
Adamovich Y, Adler J, Meltser V, Reuven N, Shaul Y.
Cell Death Differ 21(9):1451-9. doi: 10.1038/cdd.2014.60. Epub 2014 May 30. 2014
11TP73
TAp73 is essential for germ cell adhesion and maturation in testis.
Holembowski L, Kramer D, Riedel D, Sordella R, Nemajerova A, Dobbelstein M, Moll UM.
J Cell Biol 204(7):1173-90. doi: 10.1083/jcb.201306066. Epub 2014 Mar 24. 2014
12TP53, TP73
How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.
Candi E, Agostini M, Melino G, Bernassola F.
Hum Mutat 35(6):702-14. doi: 10.1002/humu.22523. Epub 2014 Mar 7. Review. 2014
13TP73
TAp73 is required for spermatogenesis and the maintenance of male fertility.
Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW.
Proc Natl Acad Sci U S A 111(5):1843-8. doi: 10.1073/pnas.1323416111. Epub 2014 Jan 21. 2014
14TP73
The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity.
Malatesta M, Peschiaroli A, Memmi EM, Zhang J, Antonov A, Green DR, Barlev NA, Garabadgiu AV, Zhou P, Melino G, Bernassola F.
Oncogene 32(39):4721-6. doi: 10.1038/onc.2012.463. Epub 2012 Oct 22. 2013
15RANBP9, TP73
Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis.
Liu T, Roh SE, Woo JA, Ryu H, Kang DE.
Cell Death Dis 4:e476. doi: 10.1038/cddis.2012.203. 2013
16NGFR, TP73
TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor.
Niklison-Chirou MV, Steinert JR, Agostini M, Knight RA, Dinsdale D, Cattaneo A, Mak TW, Melino G.
Proc Natl Acad Sci U S A 110(47):18952-7. doi: 10.1073/pnas.1221172110. Epub 2013 Nov 4. 2013
17TP73
The TP73 complex network: ready for clinical translation in cancer?
Soldevilla B, Millán CS, Bonilla F, Domínguez G.
Genes Chromosomes Cancer 52(11):989-1006. doi: 10.1002/gcc.22095. Epub 2013 Aug 1. Review. 2013
18TP73, TRIM32
Regulatory feedback loop between TP73 and TRIM32.
Gonzalez-Cano L, Hillje AL, Fuertes-Alvarez S, Marques MM, Blanch A, Ian RW, Irwin MS, Schwamborn JC, Marín MC.
Cell Death Dis 4:e704. doi: 10.1038/cddis.2013.224. 2013
19HDAC1, TP73
TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function.
Zhang J, Xu E, Chen X.
J Biol Chem 288(11):7727-37. doi: 10.1074/jbc.M112.429522. Epub 2013 Jan 29. 2013
20RANBP9, TP73
Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis.
Liu T, Roh SE, Woo JA, Ryu H, Kang DE.
Cell Death Dis 4:e476. doi: 10.1038/cddis.2012.203. 2013
21TP73
Methylation of the p73 gene in patients with myelodysplastic syndromes: correlations with apoptosis and prognosis.
Zhao Y, Fei C, Zhang X, Zhang Y, Guo J, Gu S, Li X, Chang C.
Tumour Biol 34(1):165-72. doi: 10.1007/s13277-012-0524-y. Epub 2012 Sep 28. 2013
22TP73
TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses.
Tomasini R, Secq V, Pouyet L, Thakur AK, Wilhelm M, Nigri J, Vasseur S, Berthezene P, Calvo E, Melino G, Mak TW, Iovanna JL.
Cell Death Differ 20(2):293-301. doi: 10.1038/cdd.2012.123. Epub 2012 Sep 14. 2013
23GLS2, TP73
Epigenetic silencing of glutaminase 2 in human liver and colon cancers.
Zhang J, Wang C, Chen M, Cao J, Zhong Y, Chen L, Shen HM, Xia D.
BMC Cancer 13:601. doi: 10.1186/1471-2407-13-601. 2013
24CASP8AP2, TP73
FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription.
De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V.
Oncogene 31(5):573-82. doi: 10.1038/onc.2011.274. Epub 2011 Jul 4. 2012
25TP73
The C-terminal sterile alpha motif (SAM) domain of human p73 is a highly dynamic protein, which acquires high thermal stability through a decrease in backbone flexibility.
Neira JL, Sevilla P, García-Blanco F.
Phys Chem Chem Phys 14(29):10308-23. doi: 10.1039/c2cp41179b. Epub 2012 Jun 22. 2012
26TP73
Tumor suppressor TAp73 gene specifically responds to deregulated E2F activity in human normal fibroblasts.
Ozono E, Komori H, Iwanaga R, Tanaka T, Sakae T, Kitamura H, Yamaoka S, Ohtani K.
Genes Cells 17(8):660-72. doi: 10.1111/j.1365-2443.2012.01617.x. Epub 2012 Jun 15. 2012
27RBM38, TP73
p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability.
Yan W, Zhang J, Zhang Y, Jung YS, Chen X.
Mol Cell Biol 32(13):2336-48. doi: 10.1128/MCB.00215-12. Epub 2012 Apr 16. 2012
28TP73
Regulation of p73 activity by post-translational modifications.
Conforti F, Sayan AE, Sreekumar R, Sayan BS.
Cell Death Dis 3:e285. doi: 10.1038/cddis.2012.27. Review. 2012
29TP73
Relationship between TP73 polymorphism (G4C14-A4T14) and cancer risk: a meta-analysis based on literatures.
Yu XJ, Fang F, Xie J.
Gene 484(1-2):42-6. Epub 2011 Jun 13. 2011
30RCHY1, TP73
The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation.
Jung YS, Qian Y, Chen X.
J Biol Chem 286(41):35388-95. doi: 10.1074/jbc.M111.261537. Epub 2011 Aug 18. 2011
31RCHY1, TP73
Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination.
Wu H, Zeinab RA, Flores ER, Leng RP.
Mol Cancer Res 9(12):1780-90. doi: 10.1158/1541-7786.MCR-11-0157. Epub 2011 Oct 12. 2011
32BUB1, BUB1B, BUB3, TP73
TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity.
Tomasini R, Tsuchihara K, Tsuda C, Lau SK, Wilhelm M, Ruffini A, Tsao MS, Iovanna JL, Jurisicova A, Melino G, Mak TW.
Proc Natl Acad Sci U S A 106(3):797-802. Epub 2009 Jan 12. 2009
33FAS, TP53, TP63, TP73
Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family.
Schilling T, Schleithoff ES, Kairat A, Melino G, Stremmel W, Oren M, Krammer PH, Müller M.
Biochem Biophys Res Commun 387(2):399-404. Epub 2009 Jul 16. 2009
34GATA1, TP73
p73 plays a role in erythroid differentiation through GATA1 induction.
Marqués-García F, Ferrandiz N, Fernández-Alonso R, González-Cano L, Herreros-Villanueva M, Rosa-Garrido M, Fernández-García B, Vaque JP, Marqués MM, Alonso ME, Segovia JC, León J, Marín MC.
J Biol Chem 284(32):21139-56. Epub 2009 Jun 9.PMID: 19509292 2009
35NPRL3, TP73
The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73.
Lunardi A, Chiacchiera F, D'Este E, Carotti M, Dal Ferro M, Di Minin G, Del Sal G, Collavin L.
Biochem Biophys Res Commun 388(2):428-33. Epub 2009 Aug 8.PMID: 19666006 2009
36CKAP4, TP73
p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes.
Lefkimmiatis K, Caratozzolo MF, Merlo P, D'Erchia AM, Navarro B, Levrero M, Sbisa' E, Tullo A.
Cancer Res 69(22):8563-71. Epub 2009 Oct 27.PMID: 19861536 2009
37PPP1R13B, TP53, TP53BP2, TP63, TP73
Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.
Patel S, George R, Autore F, Fraternali F, Ladbury JE, Nikolova PV.
Nucleic Acids Res 36(16):5139-51. Epub 2008 Aug 2. 2008
38GLI2, TP53, TP63, TP73
Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53.
Katoh Y, Katoh M.
Int J Oncol 33(4):881-6. 2008
39TP73, ZNF143
ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes.
Wakasugi T, Izumi H, Uchiumi T, Suzuki H, Arao T, Nishio K, Kohno K.
Oncogene 26(36):5194-203. Epub 2007 Feb 12. 2007
40HCK, TP73
Regulation of p73 by Hck through kinase-dependent and independent mechanisms.
Paliwal P, Radha V, Swarup G.
BMC Mol Biol 8:45. 2007
41TP73, TP53, TERT
C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter.
Racek T, Mise N, Li Z, Stoll A, Putzer BM.
J Biol Chem 280(49):40402-5. Epub 2005 Oct 17. 2005
42TP53, TP73, TP53INP1
TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity.
Tomasini R, Seux M, Nowak J, Bontemps C, Carrier A, Dagorn JC, Pebusque MJ, Iovanna JL, Dusetti NJ.
Oncogene 24(55):8093-104. 2005
43SHISA5, TP73
p73 induces apoptosis by different mechanisms.
Ramadan S, Terrinoni A, Catani MV, Sayan AE, Knight RA, Mueller M, Krammer PH, Melino G, Candi E.
Biochem Biophys Res Commun 331(3):713-7. Review. 2005
44KAT2B, TP73
PCAF is a coactivator for p73-mediated transactivation.
Zhao LY, Liu Y, Bertos NR, Yang XJ, Liao D.
Oncogene 22(51):8316-29. 2003
45CDKN2A, DLC1, EXT1, MLH1, PTEN, RB1, TP53, TP73
Molecular pathogenesis of human hepatocellular carcinoma.
Thorgeirsson SS, Grisham JW.
Nat Genet 31(4):339-46. 2002
46HIPK2, TP53, TP73
Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.
Kim EJ, Park JS, Um SJ.
J Biol Chem 277(35):32020-8. Epub 2002 Mar 29. 2002
47TP73
Frequent inactivation of the p73 gene by abnormal methylation or LOH in non-Hodgkin's lymphomas.
Martinez-Delgado B, Melendez B, Cuadros M, Jose Garcia M, Nomdedeu J, Rivas C, Fernandez-Piqueras J, Benitez J.
Int J Cancer 102(1):15-9. 2002
48TP73
Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.
Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, Pirnia F, Hugli B, Graber HU, De Laurenzi V, Fey MF, Melino G, Tobler A.
Cell Death Differ 8(12):1213-23. 2001
49TP73
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours.
Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F, Caput D.
Nature 404(6773):99-103. 2000
50TP73
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour.
Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, James N, McGregor JM, Harwood CA, Yulug IG, Vousden KH, Allday MJ, Gusterson B, Ikawa S, Hinds PW, Crook T, Kaelin WG Jr.
Nat Genet 25(1):47-54. 2000
51TP73
AIS is an oncogene amplified in squamous cell carcinoma.
Hibi K, Trink B, Patturajan M, Westra WH, Caballero OL, Hill DE, Ratovitski EA, Jen J, Sidransky D.
Proc Natl Acad Sci U S A 97(10):5462-7. 2000
52TP73
An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.
Pozniak CD, Radinovic S, Yang A, McKeon F, Kaplan DR, Miller FD.
Science 289(5477):304-6. 2000
53E2F1, TP73
Role for the p53 homologue p73 in E2F-1-induced apoptosis.
Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG Jr.
Nature 407(6804):645-8. 2000
54E2F1, TP73
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.
Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy SF.
Nature 407(6804):642-5. 2000
55TP73
Allelic expression of the putative tumor suppressor gene p73 in human fetal tissues and tumor specimens.
Hu JF, Ulaner GA, Oruganti H, Ivaturi RD, Balagura KA, Pham J, Vu TH, Hoffman AR.
Biochim Biophys Acta 1491(1-3):49-56. 2000
56TP73
p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent.
Ichimiya S, et al.
Oncogene 18(4):1061-6. 1999
57TP73
Overexpression of the wild type p73 gene in human bladder cancer.
Yokomizo A, et al.
Oncogene 18(8):1629-33. 1999
58D1S468, TP73
Fine mapping of distal 1p loci reveals TP73 at D1S468.
Perri P, et al.
Cytogenet Cell Genet 84(1-2):111-4. 1999
59TP73
Mutation and expression analysis of the p73 gene in prostate cancer.
Yokomizo A, et al.
Prostate 39(2):94-100. 1999
60TP73
DNA damage enables p73.
White E, et al.
Nature 399(6738):734-5, 737. No abstract available 1999
61ABL1, TP73
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.
Agami R, et al.
Nature 399(6738):809-13. 1999
62TP73
Variable expression and absence of mutations in p73 in primary neuroblastoma tumors argues against a role in neuroblastoma development.
Ejeskar K, et al.
Int J Mol Med 3(6):585-9. 1999
63TP73
Mutational analysis of the p73 gene in human breast cancers.
Shishikura T, et al.
Int J Cancer 84(3):321-5. 1999
64ABL1, TP73
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.
Yuan ZM, et al.
Nature 399(6738):814-7. 1999
65ABL1, TP73
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage.
Gong JG, et al.
Nature 399(6738):806-9. 1999
66TP73
Elevated and biallelic expression of p73 is associated withprogression of human bladder cancer.
Chi SG, et al.
Cancer Res 59(12):2791-3. 1999
67TP73, TSG1A
Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers.
Nomoto S, et al.
Cancer Res 58 : 1380-1383. 1998
68TP73
Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions.
Mai M, et al.
Genomics 51 : 359-363. 1998
69TP73
Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas.
Sunahara M, et al.
Int J Oncol 13 : 319-323. 1998
70TP73
Refined chromosomal localization of the putative tumor suppressor gene TP73.
Lo Cunsolo C, et al.
Cytogenet Cell Genet 82 : 199-201. 1998
71TP73
p73, a gene related to p53, is not mutated in esophageal carcinomas.
Nimura Y, Mihara M, Ichimiya S, Sakiyama S, Seki N, Ohira M, Nomura N, Fujimori M, Adachi W, Amano J, He M, Ping YM, Nakagawara A.
Int J Cancer 78 : 437-440. 1998
72TP73
Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines.
Kovalev S, Marchenko N, Swendeman S, LaQuaglia M, Moll UM.
Cell Growth Differ 9 : 897-903. 1998
73TP73
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.
Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D.
Cell 90(4):809-19. 1997
74TP73
P73 is a human p53-related protein that can induce apoptosis.
Jost CA, Marin MC, Kaelin WG Jr.
Nature 389(6647):191-4. Erratum in: Nature 1999 Jun 24;399(6738):817. 1997