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FLASH GENE
Symbol ENO1 contributors: mct - updated : 06-12-2011
HGNC name enolase 1, (alpha)
HGNC id 3350
Location 1p36.23      Physical location : 8.921.062 - 8.938.780
Synonym name
  • phosphopyruvate hydratase
  • 2-phospho-D-glycerate hydro-lyase
  • MYC promoter-binding protein 1
  • non-neural enolase
  • Synonym symbol(s) ENO1L1, PPH, MPB1, MBP1
    EC.number 4.2.1.11
    DNA
    TYPE functioning gene
    STRUCTURE 18.09 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure G+C rich, SP1 binding sites
    MAPPING cloned Y linked Y status confirmed
    Physical map
    VAMP3 1pter-p36.32 vesicle-associated membrane protein 3 (cellubrevin) PER3 1p36 period homolog 3 (Drosophila) UTS2 1p36 urotensin 2 TNFRSF9 1p36 tumor necrosis factor receptor superfamily, member 9 PARK7 1p36.33-p36.12 Parkinson disease (autosomal recessive, early onset) 7 MIG-6 1p36.12-36.33 mitogen-inducible gene 6 LOC390993 1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) DNB5 1p36.2-p36.1 deleted in neuroblastoma 5 RERE 1p36.1-p36.2 arginine-glutamic acid dipeptide (RE) repeats DKFZp566H0824 1p36.22 hypothetical protein DKFZp566H0824 LOC390994 1 similar to 60S ribosomal protein L23a ENO1 1p36.2 enolase 1, (alpha) LOC148915 1p36.22 hypothetical LOC148915 CA6 1p36.2 carbonic anhydrase VI LOC390995 1 similar to Solute carrier family 2, facilitated glucose transporter, member 5 (Glucose transporter type 5, small intestine) (Fructose transporter) SLC2A5 1p36.2 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 GPR157 1p36.22 G protein-coupled receptor 157 H6PD 1p36.3 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) SSB1 1p36.22 SPRY domain-containing SOCS box protein SSB-1 MGC4399 1p36.22 mitochondrial carrier protein LOC199953 1p36.22 similar to expressed sequence AV028368 PIK3CD 1p36.2 phosphoinositide-3-kinase, catalytic, delta polypeptide CLSTN1 1p36.22 calsyntenin 1 CTNNBIP1 1pter-p36.31 catenin, beta interacting protein 1 LZIC 1p36.22 leucine zipper and CTNNBIP1 domain containing NMNAT1 1p36.2 nicotinamide nucleotide adenylyltransferase 1 CRBPIV 1p36.22 retinoid binding protein 7 UBE4B 1p36.3- ubiquitination factor E4B (UFD2 homolog, yeast) KIF1B 1p36.2 kinesin family member 1B LOC388593 1 LOC388593 PGD 1p36.31 phosphogluconate dehydrogenase CORT 1p36.3-p36.2 cortistatin DFFA 1p36.3-p36.2 DNA fragmentation factor, 45kDa, alpha polypeptide PEX14 1p36.3-p36.2 peroxisomal biogenesis factor 14 LOC163301 1p36.22 similar to BC035954 protein FLJ20321 1p36.22 hypothetical protein FLJ20321
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2204 48 433 - 2002 11836316
    - - - 1400 37 336 nuclear 2002 11836316
    see MBP1
    9 - 2567 - 341 - 2010 20849415
  • shorter isoform (MBP-1)
  • localized to the nucleus, and functions as a transcriptional repressor of MYC protooncogene by binding to its promoter
  • optimal expression of this gene in tumors may lead to effective clinical therapies for cancers
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyelens   
     eyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text precocious type
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , structural protein , antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • nuclear form found in almost all the normal tissues while its expression was retained in only 35p100 of the tumors
  • basic FUNCTION
  • glycolysis, energy pathway converting 2 phospho-D-glycerate to phosphoenol-pyruvate tau-crystallin with reduced enolase activity
  • regulating MYC expression
  • has tumour suppressor activity and high level of ENO1 expression has growth inhibitory effects
  • activated NOTCH1 receptor and ENO1 cooperate in controlling MYC expression through binding the YY1 response element of the MYC promoter to regulate tumorigenesis
  • its structure exhibits distinct surface properties, explaining its various activities, including plasmin(ogen) and DNA binding
  • ENO1-mediated promotion of cell transformation and invasion partly via induced CCL20 expression
  • glycolytic enzyme that catalyses the formation of phosphoenolpyruvate in the cell cytoplasm
  • functions in repressing MYC gene expression and the loss of nuclear ENO1 expression in a large number of invasive ductal breast carcinoma may be a critical step in the development and progression of breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRAPPC2 interaction with the transcription factors ENO1, PITX1 and SF1
  • binds to the P2 c-myc promoter and competes with TATA-box binding protein (TBP) to suppress gene transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in lymphocytic hypophysitis and other autoimmune disease, and in gastric cancer
    tumoral     --over  
    prognostic role of ENO1 overexpression in head and neck cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • nuclear ENO1 appears to be a novel and valuable histochemical marker with potential prognostic value in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    MBP-1-suppressed COX2 expression plays an important role in the inhibition of growth and progression of gastric cancer
    ANIMAL & CELL MODELS