| 1 | TMPRSS2
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| Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
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| Matsuyama S, Nao N, Shirato K, Kawase M, Saito S, Takayama I, Nagata N, Sekizuka T, Katoh H, Kato F, Sakata M, Tahara M, Kutsuna S, Ohmagari N, Kuroda M, Suzuki T, Kageyama T, Takeda M.
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| Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2020 Mar 12. pii: 202002589. doi: 10.1073/pnas.2002589117. [Epub ahead of print]
2020
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| 2 | ACE2, TMPRSS2
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| SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
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| Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S.
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| Cell ell. 2020 Mar 4. pii: S0092-8674(20)30229-4. doi: 10.1016/j.cell.2020.02.052. [Epub ahead of print]
2020
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| 3 | TMPRSS2
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| Molecular Composition of Genomic TMPRSS2-ERG Rearrangements in Prostate Cancer.
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| Krumbholz M, Agaimy A, Stoehr R, Burger M, Wach S, Taubert H, Wullich B, Hartmann A, Metzler M.
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| Dis Markers 2019:5085373. doi: 10.1155/2019/5085373. eCollection 2019.
2019
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| 4 | TMPRSS2
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| TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection.
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| Iwata-Yoshikawa N, Okamura T, Shimizu Y, Hasegawa H, Takeda M, Nagata N.
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| J Virol 93(6). pii: e01815-18. doi: 10.1128/JVI.01815-18. Print 2019 Mar 15.
2019
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| 5 | TMPRSS2
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| Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer.
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| Knuuttila M, Mehmood A, Mäki-Jouppila J, Ryberg H, Taimen P, Knaapila J, Ettala O, Boström PJ, Ohlsson C, Venäläinen MS, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M.
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| Endocr Relat Cancer 25(9):807-819. doi: 10.1530/ERC-18-0148. Epub 2018 May 17.
2018
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| 6 | BRD4, TMPRSS2
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| BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer.
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| Li X, Baek G, Ramanand SG, Sharp A, Gao Y, Yuan W, Welti J, Rodrigues DN, Dolling D, Figueiredo I, Sumanasuriya S, Crespo M, Aslam A, Li R, Yin Y, Mukherjee B, Kanchwala M, Hughes AM, Halsey WS, Chiang CM, Xing C, Raj GV, Burma S, de Bono J, Mani RS.
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| Cell Rep 22(3):796-808. doi: 10.1016/j.celrep.2017.12.078.
2018
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| 7 | ERG, TMPRSS2
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| Retention of Interstitial Genes between TMPRSS2 and ERG Is Associated with Low-Risk Prostate Cancer.
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| Murphy SJ, Kosari F, Karnes RJ, Nasir A, Johnson SH, Gaitatzes AG, Smadbeck JB, Rangel LJ, Vasmatzis G, Cheville JC.
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| Cancer Res 77(22):6157-6167. doi: 10.1158/0008-5472.CAN-17-0529. Epub 2017 Nov 10.
2017
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| 8 | HPN, KLK14, KLK4, MMP3, TMPRSS2
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| Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.
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| Reid JC, Matsika A, Davies CM, He Y, Broomfield A, Bennett NC, Magdolen V, Srinivasan B, Clements JA, Hooper JD.
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| Am J Cancer Res 7(11):2257-2274. eCollection 2017.
2017
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| 9 | ERG, TMPRSS2
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| Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.
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| Mani RS, Amin MA, Li X, Kalyana-Sundaram S, Veeneman BA, Wang L, Ghosh A, Aslam A, Ramanand SG, Rabquer BJ, Kimura W, Tran M, Cao X, Roychowdhury S, Dhanasekaran SM, Palanisamy N, Sadek HA, Kapur P, Koch AE, Chinnaiyan AM.
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| Cell Rep 17(10):2620-2631. doi: 10.1016/j.celrep.2016.11.019.
2016
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| 10 | TMPRSS2
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| TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.
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| Zmora P, Moldenhauer AS, Hofmann-Winkler H, Pöhlmann S.
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| PLoS One 10(9):e0138380. doi: 10.1371/journal.pone.0138380. eCollection 2015.
2015
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| 11 | TMPRSS2
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| TMPRSS2, a novel membrane-anchored mediator in cancer pain.
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| Lam DK, Dang D, Flynn AN, Hardt M, Schmidt BL.
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| Pain 156(5):923-30. doi: 10.1097/j.pain.0000000000000130.
2015
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| 12 | TMPRSS2
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| Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.
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| Esumi M, Ishibashi M, Yamaguchi H, Nakajima S, Tai Y, Kikuta S, Sugitani M, Takayama T, Tahara M, Takeda M, Wakita T.
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| Hepatology 61(2):437-46. doi: 10.1002/hep.27426.
2015
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| 13 | ERG, TMPRSS2
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| TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia.
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| Park K, Dalton JT, Narayanan R, Barbieri CE, Hancock ML, Bostwick DG, Steiner MS, Rubin MA.
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| J Clin Oncol 32(3):206-11. doi: 10.1200/JCO.2013.49.8386. Epub 2013 Dec 2.
2014
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| 14 | TMPRSS11E, TMPRSS13, TMPRSS2
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| DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.
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| Zmora P, Blazejewska P, Moldenhauer AS, Welsch K, Nehlmeier I, Wu Q, Schneider H, Pöhlmann S, Bertram S.
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| J Virol 88(20):12087-97. doi: 10.1128/JVI.01427-14. Epub 2014 Aug 13.
2014
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| 15 | TMPRSS2
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| The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.
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| Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M.
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| J Virol 88(10):5608-16. doi: 10.1128/JVI.03677-13. Epub 2014 Mar 5.
2014
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| 16 | ACE2, ADAM17, TMPRSS2
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| TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
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| Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pöhlmann S.
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| J Virol 88(2):1293-307. doi: 10.1128/JVI.02202-13. Epub 2013 Nov 13.
2014
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| 17 | TMPRSS2
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| Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element.
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| Clinckemalie L, Spans L, Dubois V, Laurent M, Helsen C, Joniau S, Claessens F.
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| Mol Endocrinol 27(12):2028-40. doi: 10.1210/me.2013-1098. Epub 2013 Oct 9.
2013
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| 18 | TMPRSS2
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| TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
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| Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S.
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| J Virol 87(11):6150-60. doi: 10.1128/JVI.03372-12. Epub 2013 Mar 27.
2013
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| 19 | ST14, TMPRSS11D, TMPRSS2
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| Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.
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| Baron J, Tarnow C, Mayoli-Nüssle D, Schilling E, Meyer D, Hammami M, Schwalm F, Steinmetzer T, Guan Y, Garten W, Klenk HD, Böttcher-Friebertshäuser E.
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| J Virol 87(3):1811-20. doi: 10.1128/JVI.02320-12. Epub 2012 Nov 28.
2013
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| 20 | TMPRSS11D, TMPRSS2
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| Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
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| Bertram S, Heurich A, Lavender H, Gierer S, Danisch S, Perin P, Lucas JM, Nelson PS, Pöhlmann S, Soilleux EJ.
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| PLoS One 7(4):e35876. doi: 10.1371/journal.pone.0035876. Epub 2012 Apr 30.
2012
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| 21 | TMPRSS2
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| TMPRSS2-ERG-mediated feed-forward regulation of wild-type ERG in human prostate cancers.
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| Mani RS, Iyer MK, Cao Q, Brenner JC, Wang L, Ghosh A, Cao X, Lonigro RJ, Tomlins SA, Varambally S, Chinnaiyan AM.
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| Cancer Res 71(16):5387-92. Epub 2011 Jun 15.
2011
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| 22 | ERG, TMPRSS2
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| TMPRSS2-ERG Gene Fusion and Clinicopathologic Characteristics of Korean Prostate Cancer Patients.
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| Lee K, Chae JY, Kwak C, Ku JH, Moon KC.
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| Urology rology. 2010 Aug 26. [Epub ahead of print]PMID: 20800881 2010
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| 23 | ERG, TMPRSS2
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| ERG rearrangement is present in a subset of transition zone prostatic tumors.
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| Falzarano SM, Navas M, Simmerman K, Klein EA, Rubin MA, Zhou M, Magi-Galluzzi C.
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| Mod Pathol od Pathol. 2010 Aug 6. [Epub ahead of print]PMID: 20693982 2010
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| 24 | TMPRSS2, TMPRSS4
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| TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.
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| Bertram S, Glowacka I, Blazejewska P, Soilleux E, Allen P, Danisch S, Steffen I, Choi SY, Park Y, Schneider H, Schughart K, Pöhlmann S.
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| J Virol 84(19):10016-25. Epub 2010 Jul 14.PMID: 20631123 2010
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| 25 | KLK11, TMPRSS2
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| Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer.
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| Bi X, He H, Ye Y, Dai Q, Han Z, Liang Y, Zhong W.
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| Med Oncol 27(1):145-51. Epub 2009 Feb 26.PMID: 19242826 2010
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| 26 | AKT, ERG, PTEN, TMPRSS2
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| Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
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| King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL.
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| Nat Genet 41(5):524-6. Epub 2009 Apr 26.
2009
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| 27 | AKT, ERG, PTEN, TMPRSS2, TMPRSS6
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| Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
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| Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP.
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| Nat Genet 41(5):619-24. Epub 2009 Apr 26. 2009
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| 28 | ERG, TMPRSS2
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| Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer.
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| Hofer MD, Kuefer R, Maier C, Herkommer K, Perner S, Demichelis F, Paiss T, Vogel W, Rubin MA, Hoegel J.
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| Cancer Res 69(2):640-6.
2009
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| 29 | CORIN, DFNB24, DFNB25, TMPRSS11A, TMPRSS11B, TMPRSS11D, TMPRSS11E, TMPRSS11E2, TMPRSS11F, TMPRSS2, TMPRSS3, TMPRSS5
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| An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.
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| Guipponi M, Toh MY, Tan J, Park D, Hanson K, Ballana E, Kwong D, Cannon PZ, Wu Q, Gout A, Delorenzi M, Speed TP, Smith RJ, Dahl HH, Petersen M, Teasdale RD, Estivill X, Park WJ, Scott HS.
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| Hum Mutat 29(1):130-41. 2008
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| 30 | TMPRSS2
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| Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.
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| Mehra R, Tomlins SA, Yu J, Cao X, Wang L, Menon A, Rubin MA, Pienta KJ, Shah RB, Chinnaiyan AM.
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| Cancer Res 68(10):3584-90.PMID: 18483239 2008
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| 31 | ERG, TMPRSS2
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| Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data.
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| Rouzier C, Haudebourg J, Carpentier X, Valério L, Amiel J, Michiels JF, Pedeutour F.
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| Cancer Genet Cytogenet 183(1):21-7.PMID: 18474293 2008
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| 32 | TMPRSS2, ERG
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| Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers.
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| Liu W, Ewing CM, Chang BL, Li T, Sun J, Turner AR, Dimitrov L, Zhu Y, Sun J, Kim JW, Zheng SL, Isaacs WB, Xu J.
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| Genes Chromosomes Cancer 46(11):972-80. 2007
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| 33 | TMPRSS2, ETV1, ETV4
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| Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues.
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| Tu JJ, Rohan S, Kao J, Kitabayashi N, Mathew S, Chen YT.
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| Mod Pathol 20(9):921-8. Epub 2007 Jul 13. 2007
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| 34 | ERG, TMPRSS2
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| Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.
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| Clark J, Merson S, Jhavar S, Flohr P, Edwards S, Foster CS, Eeles R, Martin FL, Phillips DH, Crundwell M, Christmas T, Thompson A, Fisher C, Kovacs G, Cooper CS.
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| Oncogene 26(18):2667-73. Epub 2006 Oct 16.
2007
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| 35 | ERG, TMPRSS2
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| TMPRSS2-ERG fusion heterogeneity in multifocal prostate cancer: clinical and biologic implications.
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| Barry M, Perner S, Demichelis F, Rubin MA.
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| Urology 70(4):630-3.
2007
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| 36 | TMPRSS2, TMPRSS11D
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| Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.
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| Bšttcher E, Matrosovich T, Beyerle M, Klenk HD, Garten W, Matrosovich M.
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| J Virol 80(19):9896-8. 2006
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| 37 | TMPRSS2, ETV4, ETV1
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| TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer.
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| Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE, Cao X, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM.
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| Cancer Res 66(7):3396-400. 2006
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| 38 | ERG, ETV1, TMPRSS2
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| Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
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| Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM.
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| Science 310(5748):644-8. 2005
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| 39 | TMPRSS2, F2RL1
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| The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
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| Wilson S, Greer B, Hooper J, Zijlstra A, Walker B, Quigley J, Hawthorne S.
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| Biochem J 388(Pt 3):967-72. 2005
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| 40 | TMPRSS2
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| Cloning and characterization of the cDNA and gene for human epitheliasin.
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| Jacquinet E, Rao NV, Rao GV, Zhengming W, Albertine KH, Hoidal JR.
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| Eur J Biochem 268(9):2687-99. 2001
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| 41 | TMPRSS2
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| The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease.
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| Vaarala MH, Porvari K, Kyllonen A, Lukkarinen O, Vihko P.
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| Int J Cancer 94(5):705-10. 2001
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| 42 | TMPRSS2
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| Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.
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| Lin B, Ferguson C, White JT, Wang S, Vessella R, True LD, Hood L, Nelson PS.
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| Cancer Res 59(17):4180-4 1999
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| 43 | TMPRSS2
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| Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.
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| Paoloni-Giacobino A, Chen H, Peitsch MC, Rossier C, Antonarakis SE.
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| Genomics 44(3):309-20. 1997
|