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FLASH GENE
Symbol SERPINB13 contributors: mct - updated : 28-03-2011
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13
HGNC id 8944
Location 18q21.3      Physical location : 61.254.533 - 61.266.432
Synonym name
  • hurpin,HaCat UV-repressible protein
  • HURPIN
    • protease inhibitor 13 (hurpin, headpin)
    Synonym symbol(s) HUR7, PI13, HURPIN, HEADPIN
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 11.90 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - SERPINB5 - SERPINB13 - SERPINB4 - SERPINB3 - qter
    Authors Nakashima (00)
    Physical map
    LOC390861 18 similar to FKSG30 ZCCHC2 18q21.32 zinc finger, CCHC domain containing 2 PLEKHE1 18q21.32 pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 BCL2 18q21.33 B-cell CLL/lymphoma 2 FVT1 18q21 follicular lymphoma variant translocation 1 VPS4B 18q21.32-q21.33 vacuolar protein sorting 4B (yeast) SERPINB5 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 SERPINB12 18q21 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12 SERPINB13 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13 SERPINB4 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4 SERPINB3 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 SERPINB11 18q21.33 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11 SERPINB7 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7 SERPINB2 18q21.32-q21.33 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 SERPINB10 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10 LOC284293 18q22.1 similar to Placental thrombin inhibitor (Cytoplasmic antiproteinase) (CAP) (Protease inhibitor 6) (PI-6) SERPINB8 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8 MGC39571 18q22.1 hypothetical protein MGC39571
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3197 - 391 - 2000 11004515
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion normal oral mucosa
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a serpin domain
  • a reactive site loop near the C terminus
    • HOMOLOGY
    intraspecies homolog to SCCA1,SCCA2 serine proteinase inhibitor
    Homologene
    FAMILY member of the serpin family, ovalbumin subgroup
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • potent and selective inhibitor of the archetypal lysosomal cysteine proteinase cathepsin L (CTSL)
  • playing a physiological role to protect epithelial cells from ectopic CTSL
  • implicated in the keratinocytes UV-resistance
  • serine proteinase inhibitor (serpin) with constitutive mRNA expression in histologically normal oral mucosa
  • targets diverse mechanisms against tumor angiogenesis on which to base therapeutic strategies
  • possible involvement in inflammatory processes or the regulation of endogenous or pathogen-derived proteinase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RUNX1 binds the SERPINB13 promoter in chromatin to repress its transcription
    • cell & other
    REGULATION
    inhibited by by UV light
    repressed by RUNX1 (RUNX1 repressed SERPINB13 resulting in increased cathepsin K enzymatic activity)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in oral squamous cell carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS