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FLASH GENE

Symbol

SERPINB4

contributors: mct - updated : 28-03-2011

HGNC name	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4
HGNC id	10570

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q21.3      Physical location : 61.304.494 - 61.311.502
Synonym name	squamous cell carcinoma antigen 2 (leupin)
Synonym symbol(s)	PI11, SCCA2, LEUPIN

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	7.01 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002974 8 - 1736 - 390 - 1999 9931463

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Reproductive female system uterus cervix   highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

high molecular weight

HOMOLOGY

interspecies

homolog to murine Scca2

Homologene

FAMILY	serpin family
	OV serpin subfamily

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm

basic FUNCTION	serine proteinase inhibitor of cathepsin G and most cell kinase
	may act as a protease inhibitor to modulate the host immune response against tumor cells
	may be involved in the malignant behavior of squamous cell carcinoma cells
	with SERPINB3, stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines
	with SERPINB3, are tumor-associated proteins that can inhibit papain-like cysteine proteases, including cathepsins L, K, and S

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

carbonyl reductase may collaborate with SERPINB3 and SERPINB4 to mediate cancer behavior such as invasion or metastasis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in lung and prostate tumors tumoral     --low   in oral squamous cell carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS