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FLASH GENE
Symbol SERPINB5 contributors: mct/pgu - updated : 30-04-2010
HGNC name serpin peptidase inhibitor, clade B (ovalbumin), member 5
HGNC id 8949
Location 18q21.33      Physical location : 61.144.143 - 61.172.317
Synonym name
  • protease inhibitor 5 (maspin)
  • maspin
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
  • peptidase inhibitor 5
  • Synonym symbol(s) MASP, PI5, MASPIN
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 28.18 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    TNFRSF11A 18q21.3-q22.1 tumor necrosis factor receptor superfamily, member 11a, activator of NFKB LOC390861 18 similar to FKSG30 ZCCHC2 18q21.32 zinc finger, CCHC domain containing 2 PLEKHE1 18q21.32 pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 BCL2 18q21.33 B-cell CLL/lymphoma 2 FVT1 18q21 follicular lymphoma variant translocation 1 VPS4B 18q21.32-q21.33 vacuolar protein sorting 4B (yeast) SERPINB5 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 SERPINB12 18q21 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12 SERPINB13 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13 SERPINB4 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4 SERPINB3 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 SERPINB11 18q21.33 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11 SERPINB7 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7 SERPINB2 18q21.32-q21.33 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 SERPINB10 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10 LOC284293 18q22.1 similar to Placental thrombin inhibitor (Cytoplasmic antiproteinase) (CAP) (Protease inhibitor 6) (PI-6) SERPINB8 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8 MGC39571 18q22.1 hypothetical protein MGC39571
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2633 42 375 - 1994 8290962
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Digestiveintestine   highly Homo sapiens
     mouthtongue  highly
    Reproductivefemale systembreastmammary gland   Homo sapiens
     female systemuteruscervix highly
     male systemprostate    Homo sapiens
    Respiratorylung   highly Homo sapiens
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretoryalveolar epithelium  
    Muscularsmoothvessel   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines mammary cell line
    fluid/secretion
    at STAGE
    Text expression in embryonic endothelial cells and stromal cells
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • serine protease inhibitor domain
  • secondary structure
  • G alpha-helix (G-helix), an internal salt bridge or the P1 position of the reactive center loop, involved in the previously reported interactions of maspin with ITGB1
  • conjugated GlycoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Serpinb5 (89.1pc)
    homolog to rattus Serpinb5 (88.0pc)
    Homologene
    FAMILY
  • serpin family
  • Ov-serpin subfamily
  • CATEGORY enzyme , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • nucleocytoplasmic distribution in breast and prostate cells
  • intracellular nucleocytoplasmic protein that cannot be secreted
  • basic FUNCTION
  • inhibitor of prostate tumor progression, preventing the local invasiveness
  • inhibiting tumor growth and tumor angiogenesis, reducing osteolysis
  • playing an important role in the premalignancy of the prostate gland
  • may contribute to bladder cancer development and DNA methylation and histone deacetylation may be important for regulating maspin gene activation in bladder cancer cells
  • having a potential role for tumour metastasis in gastric cancer
  • modulating cell death and invasion in cervical cancer cells
  • might function with the cornea to regulate cell adhesion to extracellular matrix
  • blocking the growth, invasion and metastatic properties of mammary tumors
  • tumor inhibitor properties may be linked to its nuclear localization
  • suppressing the invasive ability of pancreatic ductal adenocarcinoma cells
  • plays a role in reducing the prostate tumor cell's ability to seed to bone
  • stimulates apoptosis, inhibits motility, invasion and cancer metastasis
  • may be restricted to an intracellular, possibly nuclear, role in which it influences cell-matrix interactions indirectly and is probably released only as a consequence of cell damage or necrosis
  • potentially exerts its role in the nucleus at the level of gene or chromatin regulation and thus indirectly affects the cell-matrix interaction or differentiation state
  • potent angiogenesis inhibitor and one of the key molecules that play a key role in endothelial cell (EC) cell adhesion and migration
  • affects cell adhesion and cytoskeleton reorganization through an integrin signal transduction pathway
  • decreases cell migration, invasion, proliferation, and angiogenesis, while increasing apoptosis and adhesion (
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PRSS21
  • interacts with the transcription factor IRF6
  • regulates the activation of ILK and PTK2 and causes the reorganization of the actin cytoskeleton
  • inhibits cell migration by inhibiting RAC1 and CDC42
  • physically associates with both PLAUR and ITGB1, thus producing a complex that regulates both cell motility and adhesion
  • cell & other
    REGULATION
    activated by TP53
    induced by PTEN and TP53 under hypoxic conditions in gliblastoma cells
    inhibited by PRSS21 (maybe)
    nuclear IKK-alpha activation, thereby promoting the metastatic phenotype in prostate cancer
    Other up-regulated in ovarian epithelial cells by BRCA1 185DelAG mutant protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    frequently in advanced cancer with metastases
    tumoral     --over  
    in high-grade prostate intraepithelial neoplasia (HGPIN)
    tumoral     --low  
    by hypermethylation in papillary thyroid carcinomas
    tumoral     --over  
    in lung cancer (squamous cell carcinomas) and in preneoplastic bronchial lesions
    tumoral     --over  
    by hypomethylation in a large fraction of pancreatic cancer cell lines and primary pancreatic carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • increased expression of SERPINB5 is associated with metastasis of hepatocellular carcinoma
  • detection of SERPINB5 in blood may indicate aggressive disease in breast cancer
  • Marker
  • may be a useful marker to identify the potential for progression in oral squamous cell carcinoma
  • cytoplasmic mSERPINB5 may play an important role in lung carcinomas by regulating apoptosis and thus is a favorable prognostic marker for adenocarcinoma patients whereas nuclear localization may be linked to promotion of angiogenesis
  • Therapy target
    ANIMAL & CELL MODELS