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FLASH GENE

Symbol

SERPINB3

contributors: mct - updated : 28-03-2011

HGNC name	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
HGNC id	10569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q21.3      Physical location : 61.322.432 - 61.329.197
Synonym name	squamous cell carcinoma antigen 1
Synonym symbol(s)	SCCA1, SCC, SERPINB3T4-A

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	6.77 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006919 8 splicing 1793 - 390 - 1998 9811823 SCCA1b - splicing 1540 - 338 - Y.Suminami

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Nervous brain       highly Reproductive female system uterus cervix   highly Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell Homo sapiens Blood/Hematopoietic leukocyte Homo sapiens

cell lineage
cell lines	squamous cell carcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

high molecular weight

HOMOLOGY

interspecies

homolog to C.elegans Srp2

Homologene

FAMILY

serpin family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm

basic FUNCTION	serine proteinase inhibitor of cathepsin S, K and L
	may act as a protease inhibitor to modulate the host immune response against tumor cells
	may be involved in the malignant behavior of squamous cell carcinoma cells
	with SERPINB3, stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines
	important role of SERPINB3 in the modulation of programmed cell death by different mechanisms, both in inflammatory processes and in cancer
	SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells
	its anti-protease activity might be implicated in TGF-beta1 induction
	with SERPINB4, are tumor-associated proteins that can inhibit papain-like cysteine proteases, including cathepsins L, K, and S

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

carbonyl reductase may collaborate with SERPINB3 and SERPINB4 to mediate cancer behavior such as invasion or metastasis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in T-lymphocyte peripheral to tongue squamous cell carcinoma tumoral     --low   in oral squamous cell carcinomas

Susceptibility

to progressive liver fibrosis

Variant & Polymorphism other	a novel SCCA-1 variant (SCCA-PD), presenting a single mutation in the reactive centre (Gly351Ala) associated with progressive liver fibrosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS