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FLASH GENE
Symbol SERPINB3 contributors: mct - updated : 28-03-2011
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
HGNC id 10569
Location 18q21.3      Physical location : 61.322.432 - 61.329.197
Synonym name squamous cell carcinoma antigen 1
Synonym symbol(s) SCCA1, SCC, SERPINB3T4-A
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 6.77 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC390861 18 similar to FKSG30 ZCCHC2 18q21.32 zinc finger, CCHC domain containing 2 PLEKHE1 18q21.32 pleckstrin homology domain containing, family E (with leucine rich repeats) member 1 BCL2 18q21.33 B-cell CLL/lymphoma 2 FVT1 18q21 follicular lymphoma variant translocation 1 VPS4B 18q21.32-q21.33 vacuolar protein sorting 4B (yeast) SERPINB5 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 SERPINB12 18q21 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12 SERPINB13 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13 SERPINB4 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4 SERPINB3 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 SERPINB11 18q21.33 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11 SERPINB7 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7 SERPINB2 18q21.32-q21.33 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 SERPINB10 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10 LOC284293 18q22.1 similar to Placental thrombin inhibitor (Cytoplasmic antiproteinase) (CAP) (Protease inhibitor 6) (PI-6) SERPINB8 18q21.3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8 MGC39571 18q22.1 hypothetical protein MGC39571
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 splicing 1793 - 390 - 1998 9811823
- splicing 1540 - 338 - Y.Suminami
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell Homo sapiens
Blood/Hematopoieticleukocyte Homo sapiens
cell lineage
cell lines squamous cell carcinoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
high molecular weight
HOMOLOGY
interspecies homolog to C.elegans Srp2
Homologene
FAMILY serpin family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • serine proteinase inhibitor of cathepsin S, K and L
  • may act as a protease inhibitor to modulate the host immune response against tumor cells
  • may be involved in the malignant behavior of squamous cell carcinoma cells
  • with SERPINB3, stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines
  • important role of SERPINB3 in the modulation of programmed cell death by different mechanisms, both in inflammatory processes and in cancer
  • SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells
  • its anti-protease activity might be implicated in TGF-beta1 induction
  • with SERPINB4, are tumor-associated proteins that can inhibit papain-like cysteine proteases, including cathepsins L, K, and S
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein carbonyl reductase may collaborate with SERPINB3 and SERPINB4 to mediate cancer behavior such as invasion or metastasis
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in T-lymphocyte peripheral to tongue squamous cell carcinoma
    tumoral     --low  
    in oral squamous cell carcinomas
    Susceptibility to progressive liver fibrosis
    Variant & Polymorphism other a novel SCCA-1 variant (SCCA-PD), presenting a single mutation in the reactive centre (Gly351Ala) associated with progressive liver fibrosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS