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FLASH GENE
Symbol RPS19 contributors: npt/mct - updated : 07-9-2009
HGNC name ribosomal protein S19
HGNC id 10402
Corresponding disease
DBA Diamond-Blackfan anemia
Location 19q13.2      Physical location : 42.363.987 - 42.375.482
Synonym name 40S ribosomal protein s19
Synonym symbol(s) RS19
DNA
TYPE functioning gene
STRUCTURE 11.50 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 872 - 145 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
 thymus   lowly
Digestiveliver   lowly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
Skin/Tegumentskin    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialbarrier/lining   
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines highly in primary colon carcinomas cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
conjugated RiboP
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein S19e family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text detected primarily in the nucleus, and more specifically in the nucleoli, where colocalized with the nucleolar protein nucleolin
    basic FUNCTION
  • having a function in erythropoiesis and embryogenesis and decreasing during terminal erythroid differentiation
  • having an essential role for proliferation in all cells (Robledo 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • may be interacting with RMRP
  • interacts with PIM1 that cosediments with ribosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    RPS19 reduction causes an increase in proteasome-mediated degradation of PIM1 and an inhibition of CDKN1B degradation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS