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FLASH GENE
Symbol RPS19 contributors: npt/mct - updated : 26-12-2022
HGNC name ribosomal protein S19
HGNC id 10402
Corresponding disease
DBA Diamond-Blackfan anemia
Location 19q13.2      Physical location : 42.363.987 - 42.375.482
Synonym name
  • 40S ribosomal protein s19
  • loss of heterozygosity, 19, chromosomal region 1
  • small ribosomal subunit protein eS19
  • Synonym symbol(s) RS19, DBA, DBA1, LOH19CR1, eS19
    DNA
    TYPE functioning gene
    STRUCTURE 12.67 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2021 - 145 - 2023 36413407
    6 - 2177 - 145 - 2023 36413407
    6 - 2034 - 156 - 2023 36413407
    6 - 2077 - 145 - 2023 36413407
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   lowly
    Digestiveliver   lowly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Skin/Tegumentskin    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier/lining   
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines highly in primary colon carcinomas cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
    conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
  • ribosomal protein S19e family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text detected primarily in the nucleus, and more specifically in the nucleoli, where colocalized with the nucleolar protein nucleolin
    basic FUNCTION
  • having a function in erythropoiesis and embryogenesis and decreasing during terminal erythroid differentiation
  • having an essential role for proliferation in all cells (Robledo 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • may be interacting with RMRP
  • interacts with PIM1 that cosediments with ribosomes
  • methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    RPS19 reduction causes an increase in proteasome-mediated degradation of PIM1 and an inhibition of CDKN1B degradation
    constitutional       loss of function
    leads to inflammation, TP53-dependent increase in TNF, activation of MAPK14, and decreased GATA1 expression, suggesting a novel mechanism for the erythroid defects observed in DBA
    constitutional     --low  
    causes a reduction of rRNA synthesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    evidence for targeting RPS19 for anticancer therapy enhancing antitumor T cell responses
    ANIMAL & CELL MODELS