Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

RPS19

contributors: npt/mct - updated : 26-12-2022

HGNC name	ribosomal protein S19
HGNC id	10402

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DBA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   RPS19 reduction causes an increase in proteasome-mediated degradation of PIM1 and an inhibition of CDKN1B degradation constitutional       loss of function leads to inflammation, TP53-dependent increase in TNF, activation of MAPK14, and decreased GATA1 expression, suggesting a novel mechanism for the erythroid defects observed in DBA constitutional     --low   causes a reduction of rRNA synthesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
Therapy target
	System Type Disorder Pubmed cancer     evidence for targeting RPS19 for anticancer therapy enhancing antitumor T cell responses

ANIMAL & CELL MODELS