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FLASH GENE

Symbol

RPS19

contributors: npt/mct - updated : 26-12-2022

HGNC name	ribosomal protein S19
HGNC id	10402

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	12.67 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001022 6 - 2021 NP_001013 - 145 - 2023 36413407 NM_001321484 6 - 2177 NP_001308413 - 145 - 2023 36413407 NM_001321485 6 - 2034 NP_001308414 - 156 - 2023 36413407 NM_001321483 6 - 2077 NP_001308412 - 145 - 2023 36413407

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       lowly Digestive liver       lowly Nervous brain       highly Reproductive male system prostate     highly Respiratory lung       highly Skin/Tegument skin         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial barrier/lining       Lymphoid         Muscular striatum skeletal

cell lineage
cell lines	highly in primary colon carcinomas cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

conjugated

RiboP

HOMOLOGY

Homologene

FAMILY

ribosomal protein S19e family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus
text	detected primarily in the nucleus, and more specifically in the nucleoli, where colocalized with the nucleolar protein nucleolin

basic FUNCTION	having a function in erythropoiesis and embryogenesis and decreasing during terminal erythroid differentiation
	having an essential role for proliferation in all cells (Robledo 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the small 40S ribosomal subunit

INTERACTION

DNA

RNA

binding

small molecule

protein	may be interacting with RMRP
	interacts with PIM1 that cosediments with ribosomes
	methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DBA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   RPS19 reduction causes an increase in proteasome-mediated degradation of PIM1 and an inhibition of CDKN1B degradation constitutional       loss of function leads to inflammation, TP53-dependent increase in TNF, activation of MAPK14, and decreased GATA1 expression, suggesting a novel mechanism for the erythroid defects observed in DBA constitutional     --low   causes a reduction of rRNA synthesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
Therapy target
	System Type Disorder Pubmed cancer     evidence for targeting RPS19 for anticancer therapy enhancing antitumor T cell responses

ANIMAL & CELL MODELS