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FLASH GENE
Symbol RPS19 contributors: npt/mct - updated : 07-9-2009
HGNC name ribosomal protein S19
HGNC id 10402
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
conjugated RiboP
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein S19e family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text detected primarily in the nucleus, and more specifically in the nucleoli, where colocalized with the nucleolar protein nucleolin
    basic FUNCTION
  • having a function in erythropoiesis and embryogenesis and decreasing during terminal erythroid differentiation
  • having an essential role for proliferation in all cells (Robledo 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • may be interacting with RMRP
  • interacts with PIM1 that cosediments with ribosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    RPS19 reduction causes an increase in proteasome-mediated degradation of PIM1 and an inhibition of CDKN1B degradation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS