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FLASH GENE
Symbol RPS19 contributors: npt/mct - updated : 26-12-2022
HGNC name ribosomal protein S19
HGNC id 10402
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
conjugated RiboP
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein S19e family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text detected primarily in the nucleus, and more specifically in the nucleoli, where colocalized with the nucleolar protein nucleolin
    basic FUNCTION
  • having a function in erythropoiesis and embryogenesis and decreasing during terminal erythroid differentiation
  • having an essential role for proliferation in all cells (Robledo 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • may be interacting with RMRP
  • interacts with PIM1 that cosediments with ribosomes
  • methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    RPS19 reduction causes an increase in proteasome-mediated degradation of PIM1 and an inhibition of CDKN1B degradation
    constitutional       loss of function
    leads to inflammation, TP53-dependent increase in TNF, activation of MAPK14, and decreased GATA1 expression, suggesting a novel mechanism for the erythroid defects observed in DBA
    constitutional     --low  
    causes a reduction of rRNA synthesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
    • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    evidence for targeting RPS19 for anticancer therapy enhancing antitumor T cell responses
    ANIMAL & CELL MODELS