| protein
| collaborating with CYP27B1 in modulating skeletal and calcium homeostasis |
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inhibiting SOST transcription |
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binding with PTHR modified by mutation of PTH and PTHLH (induce a conformational change in the PTH1R that promotes arrestin binding and dissociates SlC9A3R1 from PTH1R internalization)  |
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regulate EFNBB2 to act in a paracrine or autocrine manner on EEPHB4 or EPHB2 in the osteoblast |
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GNAQ signal plays an inhibitory role in the PTH osteoanabolic action, suggesting that its suppression may lead to a novel treatment in combination with PTH against osteoporosis |
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interacting with ELF4 (is involved in PTH suppression of osteoblasts through activating the MAP2K4/MAPK8 pathway and subsequently up-regulating MAB21L1 expression |
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anabolic action of PTH on bone formation requires FGF2 |
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is a novel PTH-responsive factor regulating immune cells and PTH actions on marrow hematopoietic progenitor cells |
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PRG4 is a PTH-responsive gene in bone and liver, and is a dynamic regulator of skeletogenesis and PTH skeletal anabolism |
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POSTN could be involved in the regulation of SOST expression and bone anabolism in response to PTH |
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LRP6 is required for parathyroid hormone (PTH)-stimulated signaling pathways in osteoblasts |
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PTH upregulates TNFSF11 expression in osteocytes and resorption induced by PTH receptor signaling in the adult skeleton requires direct regulation of the TNFSF11 gene in osteocytes |
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activates the orphan nuclear receptor NR4A2 to induce FGF23 transcription |
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PTH is a major regulator of both transcription and translation, and KHSRP binds SLC34A1 mRNA but its role in PTH regulation of SLC34A1 mRNA is not clear |
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PTH can stimulate a novel negative feedback of its anabolic actions by stimulating TNFSF1l and PTGS2 expression |
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the kidney expresses a CASR that might directly contribute to the regulation of many aspects of renal function in a PTH-independent manner |
