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FLASH GENE
Symbol HPX contributors: - updated : 14-06-2006
HGNC name hemopexin
HGNC id 5171
Location 11p15.5      Physical location : 6.452.267 - 6.462.254
Synonym name hemopexin, beta 1 glycoprotein of blood serum
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC390084 11 similar to Olfactory receptor 56A4 LOC338751 11p15.4 similar to Olfactory receptor 52L1 LOC390085 11 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC120793 11p15.4 similar to Olfactory receptor 56A4 LOC120796 11p15.4 similar to Olfactory receptor 56A1 LOC390086 11 similar to Olfactory receptor 56A1 LOC390087 11 similar to Olfactory receptor 52L2 OR52X1P 11p15.3 olfactory receptor, family 52, subfamily X, member 1 pseudogene LOC196335 11p15.4 similar to Olfactory receptor 56B4 LOC390088 11 similar to seven transmembrane helix receptor LOC390089 11 hypothetical gene supported by AF359415 LOC255725 11p15.4 similar to seven transmembrane helix receptor LOC120787 11p15.4 similar to seven transmembrane helix receptor MGC34805 11p15.4 hypothetical protein MGC34805 DKFZP566M1046 11p15.4 hypothetical protein DKFZp566M1046 CNGA4 11p15.4 cyclic nucleotide gated channel alpha 4 CCKBR 11p15.4 cholecystokinin B receptor PRKCDBP 11p15.5-p15.4 protein kinase C, delta binding protein SMPD1 11p15.3 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) APBB1 11p15.5 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) HPX 11p15.5 hemopexin TRIM3 11p15.5 tripartite motif-containing 3 ARFIP2 11p15 ADP-ribosylation factor interacting protein 2 (arfaptin 2) FXC1 11p15.2-p15.5 fracture callus 1 homolog (rat) LOC390090 11 similar to voltage-dependent anion channel 1 FLJ35709 11p15.4 hypothetical protein FLJ35709 LOC387749 11 hypothetical gene supported by BX647806 LOC196337 11p15.4 hypothetical protein LOC196337 LOC387750 11 similar to SI:zC220F6.1 (novel protein similar to human dynein heavy chain (DHC)) FLJ32752 11p15.4 hypothetical protein FLJ32752 KIAA0409 11p15.5-p15.2 hypothetical protein FLJ32752 ILK 11p15.3 integrin-linked kinase TAF10 11p15.3 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa CLN2 11p15.3 ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease) PCDH16 11p15.4 protocadherin 16 dachsous-like (Drosophila) MRPL17 11p15.5-p15.4 mitochondrial ribosomal protein L17 LOC387751 11 similar to very large inducible GTPase-1 LOC338755 11p15.4 similar to Olfactory receptor 2AG1 (HT3) LOC144125 11p15.4 similar to Olfactory receptor 2AG1 (HT3) OR6A1 11p15.5 olfactory receptor, family 6, subfamily A, member 1 JCG6 11p15.4 olfactory receptor-like protein JCG6 LOC341276 11p15.4 similar to hP4 olfactory receptor
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   specific
Lymphoid/Immunespleen   moderately
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one high affinity binding site for heme
  • five hemopexin-like domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Hpx
    ortholog to murine Hpxn
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • transporting heme to hepatocytes for iron salvage
  • binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS homeostasis , extracellular transport
    text
  • iron ion homeostasis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Fe2+
  • heme
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS