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Symbol WEE1 contributors: mct/ - updated : 02-07-2016
HGNC name WEE1 homolog (S. pombe)
HGNC id 12761
Location 11p15.4      Physical location : 9.595.227 - 9.611.311
Synonym name
  • WEE1+ homolog (S. pombe)
  • wee1-like protein kinase
  • Wee1A kinase
  • Synonym symbol(s) FLJ16446, WEE1A, DKFZp686I18166
    TYPE functioning gene
    STRUCTURE 16.09 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure SP1/CPBP motif located between -252 bp and the start codon of the promoter
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC283118 11p15.3 hypothetical LOC283118 RPL27A 11p15.5 ribosomal protein L27a ST5 11p15 suppression of tumorigenicity 5 C11orf17 11p15.3 chromosome 11 open reading frame 17 C11orf16 11p15.3 chromosome 11 open reading frame 16 ASCL3 11p15.3 achaete-scute complex (Drosophila) homolog-like 3 C11orf15 11p15.3 chromosome 11 open reading frame 15 NRIP3 11p15.3 nuclear receptor interacting protein 3 SCUBE2 11p15.3 signal peptide, CUB domain, EGF-like 2 FLJ46111 11p15.3 FLJ46111 protein RAB6IP1 11p15.3 RAB6 interacting protein 1 KIAA0033 11p15.3 KIAA0033 protein IPO7 11p15.3 importin 7 ZNF143 11p15.4-p15.3 zinc finger protein 143 (clone pHZ-1) WEE1 11p15.3 WEE1 homolog (S. pombe) LOC387752 11 similar to 60S ribosomal protein L23a LOC387753 11 similar to 60S ribosomal protein L21 SWAP70 11p15 Homo sapiens SWAP-70 protein (SWAP70), mRNA. CMT4B2 11p15.3 Charcot-Marie-Tooth neuropathy 4B2 (autosomal recessive, with myelin outfolding) ADM 11p15.4 adrenomedullin
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3374 - 646 - -
    11 - 3234 - 432 - 2005 PMID: 158044
  • also called WWE1 I
  • uses Met215 of WEE1 as its initiation codon
  • provide constitutive WEE1-like kinase activity to inhibit mitotic cell proliferation
  • may play an important role in differentiation and in tumor suppression
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vessel   moderately
    Digestivemouthtongue  moderately
    Reproductivefemale systemplacenta  moderately
     female systembreastmammary gland highly
     female systemuterus  moderately
    Urinarybladder   highly
    Visualeye   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    cell cycle     cell cycle, interphase, S, G2
    Text placenta
  • N-terminal 214 residues facilitating its ubiquitin-dependent degradation to trigger mitotic entry
  • a protein kinase domain
    interspecies homolog to yeast wee1
    homolog to murine Wee1
  • protein kinase superfamily
  • SER/THR family of protein kinases
  • WEE1 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • negative regulator of cell cycle
  • phosphorylation cyclin dependent kinases
  • insuring the completion of DNA replication prior to mitosis
  • playing a critical role in controlling the transition into mitosis when it involved in the Swe1-Cdk1 complex
  • inhibiting mitosis entry by phosphorylating cyclin B1/CDC2 (M phase promoting factor (MPF))
  • repression of WEE1 by Kruppel-like factor 2 (KLF2) is involved in DNA damage-induced apoptosis
  • cell-cycle checkpoint kinase that regulates the entry into mitosis in dividing cells
  • plays a key role in cell cycle progression at the onset of mitosis by phosphorylating CDK1 at the inhibitory Tyr15 AA residue
  • major regulator of the G(2) checkpoint in glioblastoma cells
  • protein kinase that negatively regulates mitotic entry in G2 phase by suppressing cyclin B-CDC2 activity
  • regulator of genomic stability
  • specifically protects the stability of stalled replication forks
  • may have important role in hypoxia- induced pathophysiological situations in endothelial cells
  • cell-cycle checkpoint regulator
  • CELLULAR PROCESS cell cycle, division, mitosis
    a component
    small molecule nucleotide,
  • ATP
  • protein
  • phosphorylating Y15 in CDC2 and other CDKs
  • CDK1
  • regulation of WEE1 by BRSK2 and BRSK1 is essential for the differentiation of polarized neurons
  • interacting with CSNK2B (participates in PLK1-WEE1 complex formation interacting directly with WEE1 and thereby contributing to the regulation of G2-M cell cycle transition)
  • USP50 may act through a HSP90AA1-dependent mechanism to counteract CDC25B mitotic inducing activity and prevent WEE1 degradation
  • WEE1 interacting with MUS81 (novel role of WEE1 in controlling MUS81 and DNA replication in human cells)
  • plays an important role in the regulation of WEE1 stability
  • CDC14A counteracts CDK1-CCNB1 activity through WEE1 dephosphorylation
  • both WEE1 and MYT1 can phosphorylate CDK1
  • ERRFI1 controls mitotic progression and the G2/M DNA damage checkpoint by stabilizing the WEE1 Kinase
  • cell & other
  • regulator of both HIV type 1 Vpr and gamma irradiation-induced apoptosis
    activated by transactivated by and increased in association with FOS/JUN (AP1)
    Cdk1 Phosphorylation
    inhibited by inactivated in phase M and G1 by autophosphorylation and protein degradation
    repressed by KLF2, by directly binding to an SP1/CPBP motif located between -252 bp and the start codon of the WEE1 promoter
    Phosphorylated by BRSK2, BRSK1 that are required to initiate its downregulation in polarized neurons
    Other regulation of its localization around the SPB (spindle pole body) during the G2/M transition is important for proper mitotic entry and progression
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    constitutional     --over  
    in rheumatoid cells inducing aberrant mitosis
    constitutional     --over  
    with PKMYT1 induced the phosphorylation of CDC2 leading to G2/M arrest
    constitutional     --low  
    caused a block in DNA replication, resulting in accumulation of cells in S phase
    Variant & Polymorphism
    Candidate gene
    Therapy target
    combination of WEE1 inhibitor and TNFSF10 could provide a novel combination for the treatment of basal/triple-negative breast cancer
    inhibition of WEE1 kinase holds potential as a therapeutic approach in treatment of glioblastoma