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FLASH GENE
Symbol PGK1 contributors: mct/npt - updated : 17-06-2020
HGNC name phosphoglycerate kinase 1
HGNC id 8896
Corresponding disease
PGK1D phosphoglycerate kinase 1 deficiency
Location Xq21.1      Physical location : 77.359.665 - 77.382.322
Synonym name
  • primer recognition protein 2
  • cell migration-inducing gene 10 protein
    • Synonym symbol(s) PGK, PGKA, MGC117307, MGC142128, MGC8947, MIG10,HEL-S-68p
    EC.number 2.7.2.3
    DNA
    TYPE functioning gene
    STRUCTURE 22.66 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - DXZ1 - PGK1P1 - DXS1 - DXS159 - DXS153 - GJB1 - TAF1 - DXS131 ,DXS162 - PHKA1 - DXS227 - XIST ,DXS128 - DXS441 - DXS171 - DXS347 - DXS325 - DXS356 - DXS56 - MNK - PGK1P1 - DXS346 ,DXS447 - DXS72 - qter
    Authors Lafrenière (91), Consensus (93)
    Text see ED1 , GJB1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2439 - 417 - 2019 31492635
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  moderately Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Pgk1
    Homologene
    FAMILY
  • phosphoglycerate kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphoglycerate kinase involved in glycolysis
  • key enzyme for ATP generation and energy pathway
  • might be a potential protein biomarker of intracellular oxidative status (Jang 2008)
  • PGK1 and PGK2 are involved in spermatogenesis and thought to be related to sperm motility
  • important dual roles of PGK1 as a glycolytic enzyme and a protein kinase in the mutual regulation of cell metabolism and autophagy in maintaining cell homeostasis
  • PGK1 catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP and produces 3-phosphoglycerate and ATP
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis
  • protein phosphatase activity of PTEN dephosphorylates and inhibits autophosphorylated PGK1, thereby inhibiting glycolysis, ATP production, and brain tumor cell proliferation
    • cell & other
    REGULATION
    induced by hydrogen peroxide
    ASSOCIATED DISORDERS
    corresponding disease(s) PGK1D
    related resource Retinal Information Network
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased in the testis with ageing
    tumoral     --over  
    leads to tumor cell proliferation
    tumoral     --over  
    is associated with poor prognosis in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker may serve as a promising biomarker for breast cancer
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may serve as a promising target therapy for breast cancer
    ANIMAL & CELL MODELS