Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IL2RG contributors: mct/ - updated : 10-04-2006
HGNC name interleukin 2 receptor, gamma
HGNC id 6010
Corresponding disease
SCIDX1 severe combined immunodeficiency, X-linked 1
Location Xq13.1      Physical location : 70.327.253 - 70.331.481
Synonym name
  • CD132 antigen
  • IL-2 receptor subunit gamma
  • common cytokine receptor gamma chain
  • Synonym symbol(s) IMD4, CD132
    DNA
    TYPE functioning gene
    STRUCTURE 4.23 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - DXZ1 - DXS159 - DXS467 - DXS153 - [DXS135 - DXS339 - DXS106 - DXS132 ,DXS732 - DXS453 - DXS348 ],IL2RG - GJB1 - qter
    Physical map
    FLJ25989 Xq13.1 FLJ25989 protein LOC158833 Xq13.1 hypothetical protein LOC158833 P2RY4 Xq13 pyrimidinergic receptor P2Y, G-protein coupled, 4 ARR3 Xq13.1 arrestin 3, retinal (X-arrestin) LOC347517 Xq13.1 similar to DNA segment, Chr 9, Brigham & Womens Genetics 0185 expressed LOC51248 Xq13.1 hypothetical protein LOC51248 KIF4A Xq13.1 kinesin family member 4A OBDPF Xq13.1 osteoblast differentiation promoting factor DLG3 Xq13.1 discs, large (Drosophila) homolog 3 (neuroendocrine-dlg) TEX11 Xq12-q13.1 testis expressed sequence 11 SLC7A3 Xq12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 LOC392488 X similar to Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) SNX12 Xq12-q13.1 sorting nexin 12 MLLT7 Xq13.1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 LOC158830 Xq13.1 similar to Ab2-183 IL2RG Xq12-q13.1 interleukin 2 receptor, gamma (severe combined immunodeficiency) TNRC11 Xq13 trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit) NLGN3 Xq13.1 neuroligin 3 GJB1 Xq13.1 gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) ZNF261 Xq13.1 zinc finger protein 261 NONO Xq13.1 non-POU domain containing, octamer-binding ITGB1BP2 Xq12.1-q13 integrin beta 1 binding protein (melusin) 2 LOC392489 X similar to ras homolog gene family, member G (rho G); RhoG TAF1 Xq13.1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa ING2 Xq12 inhibitor of growth family, member 2 OGT Xq13 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) ACRC Xq13.1 acidic repeat containing CXCR3 Xq13 chemokine (C-X-C motif) receptor 3 LOC158825 Xq13.1 hypothetical LOC158825 LOC389868 X LOC389868 LOC389869 X LOC389869 LOC389870 X LOC389870 LOC389871 X LOC389871
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1560 - 369 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Lymphoid/Immunelymph node   moderately
     spleen   moderately
     thymus   highly
     tonsils   highly
    cell lineage in lymphoid and myeloid cell lineages predominantly
    cell lines
    fluid/secretion blood predominantly
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 22 aa signal peptide
  • a fibronectin type III domain containing a WSXWS motif
  • a box 1 motif
  • conjugated GlycoP
    isoforms Precursor a 347 mature peptide of 40 kda
    HOMOLOGY
    interspecies ortholog to rattus Il2rg
    ortholog to murine Il2rg
    Homologene
    FAMILY
  • hematopoietic receptor family
  • type I cytokine receptor family
  • type 5 subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • single-pass type I transmembrane protein
  • external side of plasma membrane
  • basic FUNCTION
  • interleukin 2, high affinity receptor gamma chain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • functional component of IL2R, IL4R, IL7R, IL9R, IL15R, IL21R and IL13R (see SCIDX1)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCIDX1
    related resource X-Linked Severe Combined Immunodeficiency SCID
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS