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FLASH GENE
Symbol DDX3Y contributors: mct/npt - updated : 19-03-2009
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
HGNC id 2699
Corresponding disease
AZFA nonobstructive spermatogenic failure
Location Yq11.21      Physical location : 15.016.018 - 15.032.390
Synonym name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome
  • DEAD box protein 3, Y-chromosomal
  • Synonym symbol(s) DBY
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 15.69 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392590 Y similar to RCC1-like ASSP6 Yq11.22 argininosuccinate synthetase pseudogene 6 ADLICANP Yq11.21 adlican pseudogene RPS24P1 Yq11.23 ribosomal protein S24 pseudogene 1 LOC386726 ARSEP Yq11.2 arylsulfatase E pseudogene ARSDP Yq11.2 arylsulfatase D pseudogene GYG2P Yq11.23 glycogenin 2 pseudogene APXLP Yq11.23 apical protein-like (Xenopus laevis) pseudogene LOC359791 Yq11.1 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa pseudogene TTTY15 Yq11.1 testis-specific transcript, Y-linked 15 USP9Y Yq11.23 ubiquitin specific protease 9, Y chromosome (fat facets-like Drosophila) CDY4P Yq11.2 chromodomain protein, Y-linked 4 pseudogene DDX3Y Yq11.11-q11.21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked CASKP Yq11 calcium/calmodulin-dependent serine protein kinase (MAGUK family) pseudogene SFPQP Yq11.23 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) pseudogene UTY Yq11.1-q11.21 ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome PSMA6P Yq11.1 proteasome (prosome, macropain) subunit, alpha type, 6 pseudogene TMSB4Y Yq11.1-q11.22 thymosin, beta 4, Y chromosome LOC360022 Yq11 PC4 and SFRS1 interacting protein 2 pseudogene KALP Yq11.21 Kallmann syndrome sequence pseudogene VCY Yq11.21 variable charge, Y chromosome NLGN4Y Yq11.21 neuroligin 4, Y linked LOC359793 Yq11.21 hypothetical protein FLJ10842 pseudogene HCP46 Yq11.221 cytochrome c, somatic pseudogene
    regionally located in a AZF deleted region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4420 73 660 - Lhan, Rosinski (2008)
    long 3' utr
    - - 2320 73 660 testis Lhan, Rosinski (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DEAD/H box (Asp-Glu-Ala-Asp/His)
  • helicase C terminal conserved domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX3/DED1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putative RNA helicase
  • playing an important role during spermatogenesis (Lardone 2007)
  • contributing to the function of spermatogonia
  • encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells (Rosinski 2008)
  • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AZFA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS