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FLASH GENE
Symbol DDX3Y contributors: mct/npt - updated : 19-03-2009
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
HGNC id 2699
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp-Glu-Ala-Asp/His)
  • helicase C terminal conserved domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX3/DED1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putative RNA helicase
  • playing an important role during spermatogenesis (Lardone 2007)
  • contributing to the function of spermatogonia
  • encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells (Rosinski 2008)
  • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AZFA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS