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FLASH GENE

Symbol

DDX3Y

contributors: mct/npt - updated : 19-03-2009

HGNC name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
HGNC id	2699

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     predominantly

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatogonia

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DEAD/H box (Asp-Glu-Ala-Asp/His)
	helicase C terminal conserved domain

HOMOLOGY

Homologene

FAMILY	DEAD box helicase family
	DDX3/DED1 subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	putative RNA helicase
	playing an important role during spermatogenesis (Lardone 2007)
	contributing to the function of spermatogonia
	encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells (Rosinski 2008)

CELLULAR PROCESS	cell life, differentiation
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

binding

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AZFA

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS