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FLASH GENE
Symbol DDX3Y contributors: mct/npt - updated : 19-03-2009
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
HGNC id 2699
Corresponding disease
AZFA nonobstructive spermatogenic failure
Location Yq11.21      Physical location : 15.016.018 - 15.032.390
Synonym name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome
  • DEAD box protein 3, Y-chromosomal
  • Synonym symbol(s) DBY
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 15.69 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located in a AZF deleted region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 4420 73 660 - Lhan, Rosinski (2008)
    long 3' utr
    - - 2320 73 660 testis Lhan, Rosinski (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DEAD/H box (Asp-Glu-Ala-Asp/His)
  • helicase C terminal conserved domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX3/DED1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • putative RNA helicase
  • playing an important role during spermatogenesis (Lardone 2007)
  • contributing to the function of spermatogonia
  • encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells (Rosinski 2008)
  • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AZFA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS