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FLASH GENE

Symbol

PDCD5

contributors: mct/npt - updated : 10-04-2019

HGNC name	programmed cell death 5
HGNC id	8764

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   and nuclear translocation of PDCD5 in rheumatoid arthritis patient-derived fibroblast-like synoviocytes undergoing apoptosis (Wang 2007) tumoral     --low   associated with high-grade astrocytic gliomas (Li 2008) tumoral     --low   in the high malignant group of glioma significantly decreased compared with the low malignant group tumoral     --low   may contribute to the pathogenesis of human ovarian serous cystadenocarcinomas

Susceptibility

to lung cancer risk and prognosis

Variant & Polymorphism other	rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis (Spinola 2006)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma PDCD5 mRNA expressions is promising target for the diagnosis and treatment of glioma

ANIMAL & CELL MODELS

Pdcd5 knockout in mouse embryos results in placental defects and embryonic lethality