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FLASH GENE
Symbol PDCD5 contributors: mct/npt - updated : 10-04-2019
HGNC name programmed cell death 5
HGNC id 8764
Location 19q13.11      Physical location : 33.072.103 - 33.078.322
Synonym name
  • TF-1 cell apoptosis related gene 19 protein
  • TFAR19 novel apoptosis-related
    • Synonym symbol(s) TFAR19, MGC9294
    DNA
    TYPE functioning gene
    STRUCTURE 6.26 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure 5'-upstream region contains a highly active TATA-less promoter that is up-regulated by etoposide
    MAPPING cloned Y linked   status provisional
    Map cen - D19S414 - PDCD5 - D19S225 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 604 - 125 - 2017 28051100
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue  highly
    Reproductivefemale systemuterus  highly
     male systemtestis  highly
    cell lineage
    cell lines tumor cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • PDCD5 family
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • can accelerate apoptosis in different type of cells in response to different stimuli, and during this process, PDCD5 rapidly translocates from the cytoplasm to the nucleus
    • basic FUNCTION
  • enhancing apoptosis triggered by growth factor or serum deprivation
  • putatively playing a general role in the apoptotic process
  • target gene under the control of some important apoptosis-related transcriptional factors during the cell apoptosis
  • may play a key role to regulate the apoptotic processes in the gastric cancer cells and gastric tumors (Yang 2006)
  • mediates apoptosis and may be involved in the pathogenesis of rheumatoid arthritis (Wang 2007)
  • may play a dual role in the KAT5 pathway and after DNA damage, functions as a KAT5 coactivator to promote apoptosis (Xu 2009)
  • PDCD5 serves as a guardian of immunological functions
  • might exert its apoptotic function at least in part through inhibition of TUBB folding
  • functions as a co-activator of TP53 and regulates TP53-dependent cell fate decisions via the mediation of TP53 dynamics
  • has complex biological functions, including programmed cell death and immune regulation
  • PDCD5 may be a novel tumor suppressor gene
  • PDCD5 suppresses AKT1-mediated cytoprotection of endothelium
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with KAT5 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis (Xu 2009)
  • DNAJB1 interacts with PDCD5 and induces the ubiquitin-dependent proteasomal degradation of PDCD5, thereby inhibiting TP53-mediated apoptosis
  • essential role for the PDCD5-OTUD5 network in TP53 activation
  • PDCD5 selectively mediates HDAC3 dissociation from TP53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degradation
  • PDCD5 interacts with the TP53 pathway to promote cell apoptosis
  • PDCD5 participates likely in immune regulation by promoting regulatory T cell function via the PDCD5-KAT5-FOXP3 pathway
  • PPEF1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to PDCD5 destabilization
  • PPEF1 suppressed TP53-mediated genotoxic stress response via negative regulation of PDCD5
  • PDCD5 competitively inhibited interaction between histone deacetylase 3 (HDAC3) and AKT1
  • STK31 interacts with PDCD5, which maintains the stability of PDCD5
  • STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress
    • cell & other
    REGULATION
    activated by activated in cells undergoing apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    and nuclear translocation of PDCD5 in rheumatoid arthritis patient-derived fibroblast-like synoviocytes undergoing apoptosis (Wang 2007)
    tumoral     --low  
    associated with high-grade astrocytic gliomas (Li 2008)
    tumoral     --low  
    in the high malignant group of glioma significantly decreased compared with the low malignant group
    tumoral     --low  
    may contribute to the pathogenesis of human ovarian serous cystadenocarcinomas
    Susceptibility
  • to lung cancer risk and prognosis
    • Variant & Polymorphism other
  • rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis (Spinola 2006)
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    PDCD5 mRNA expressions is promising target for the diagnosis and treatment of glioma
    ANIMAL & CELL MODELS
  • Pdcd5 knockout in mouse embryos results in placental defects and embryonic lethality