protein
| interacts with KAT5 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis (Xu 2009) |
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DNAJB1 interacts with PDCD5 and induces the ubiquitin-dependent proteasomal degradation of PDCD5, thereby inhibiting TP53-mediated apoptosis |
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essential role for the PDCD5-OTUD5 network in TP53 activation |
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PDCD5 selectively mediates HDAC3 dissociation from TP53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degradation |
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PDCD5 interacts with the TP53 pathway to promote cell apoptosis |
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PDCD5 participates likely in immune regulation by promoting regulatory T cell function via the PDCD5-KAT5-FOXP3 pathway |
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PPEF1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to PDCD5 destabilization |
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PPEF1 suppressed TP53-mediated genotoxic stress response via negative regulation of PDCD5 |
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PDCD5 competitively inhibited interaction between histone deacetylase 3 (HDAC3) and AKT1 |
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STK31 interacts with PDCD5, which maintains the stability of PDCD5 |
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STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress |