Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PDCD5 contributors: mct/npt - updated : 10-04-2019
HGNC name programmed cell death 5
HGNC id 8764
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • PDCD5 family
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • can accelerate apoptosis in different type of cells in response to different stimuli, and during this process, PDCD5 rapidly translocates from the cytoplasm to the nucleus
    • basic FUNCTION
  • enhancing apoptosis triggered by growth factor or serum deprivation
  • putatively playing a general role in the apoptotic process
  • target gene under the control of some important apoptosis-related transcriptional factors during the cell apoptosis
  • may play a key role to regulate the apoptotic processes in the gastric cancer cells and gastric tumors (Yang 2006)
  • mediates apoptosis and may be involved in the pathogenesis of rheumatoid arthritis (Wang 2007)
  • may play a dual role in the KAT5 pathway and after DNA damage, functions as a KAT5 coactivator to promote apoptosis (Xu 2009)
  • PDCD5 serves as a guardian of immunological functions
  • might exert its apoptotic function at least in part through inhibition of TUBB folding
  • functions as a co-activator of TP53 and regulates TP53-dependent cell fate decisions via the mediation of TP53 dynamics
  • has complex biological functions, including programmed cell death and immune regulation
  • PDCD5 may be a novel tumor suppressor gene
  • PDCD5 suppresses AKT1-mediated cytoprotection of endothelium
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with KAT5 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis (Xu 2009)
  • DNAJB1 interacts with PDCD5 and induces the ubiquitin-dependent proteasomal degradation of PDCD5, thereby inhibiting TP53-mediated apoptosis
  • essential role for the PDCD5-OTUD5 network in TP53 activation
  • PDCD5 selectively mediates HDAC3 dissociation from TP53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degradation
  • PDCD5 interacts with the TP53 pathway to promote cell apoptosis
  • PDCD5 participates likely in immune regulation by promoting regulatory T cell function via the PDCD5-KAT5-FOXP3 pathway
  • PPEF1 interacts with and dephosphorylates PDCD5 at Ser-119, which leads to PDCD5 destabilization
  • PPEF1 suppressed TP53-mediated genotoxic stress response via negative regulation of PDCD5
  • PDCD5 competitively inhibited interaction between histone deacetylase 3 (HDAC3) and AKT1
  • STK31 interacts with PDCD5, which maintains the stability of PDCD5
  • STK31 is a positive apoptosis regulator that inhibits tumorigenesis of colon cancer cells by inducing PDCD5-mediated apoptosis in response to genotoxic stress
    • cell & other
    REGULATION
    activated by activated in cells undergoing apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    and nuclear translocation of PDCD5 in rheumatoid arthritis patient-derived fibroblast-like synoviocytes undergoing apoptosis (Wang 2007)
    tumoral     --low  
    associated with high-grade astrocytic gliomas (Li 2008)
    tumoral     --low  
    in the high malignant group of glioma significantly decreased compared with the low malignant group
    tumoral     --low  
    may contribute to the pathogenesis of human ovarian serous cystadenocarcinomas
    Susceptibility
  • to lung cancer risk and prognosis
    • Variant & Polymorphism other
  • rs1862214 polymorphism in PDCD5 is predictive for lung cancer risk and prognosis (Spinola 2006)
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    PDCD5 mRNA expressions is promising target for the diagnosis and treatment of glioma
    ANIMAL & CELL MODELS
  • Pdcd5 knockout in mouse embryos results in placental defects and embryonic lethality