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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ABI3BP

contributors: mct/npt - updated : 11-07-2009

HGNC name	ABI family, member 3 (NESH) binding protein
HGNC id	17265

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in lung cancer tumoral     --low   reduced expression led to the dysfunction of G1/S transition in cell cycle, which may have partially caused the growth inhibition in replicative senescence (Wakoh 2009) tumoral     --low   in most malignant thyroid tumors of all types (Latini 2008)

Susceptibility

Variant & Polymorphism

Candidate gene	biomarker for lung cancer development as well as a molecular adjunct for lung carcinogenesis in human
Marker
Therapy target	Activation of ABI3BP or its pathway may represent a possible basis for targeted therapy of certain cancers (Latini 2008)

ANIMAL & CELL MODELS