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FLASH GENE

Symbol

ABI3BP

contributors: mct/npt - updated : 11-07-2009

HGNC name	ABI family, member 3 (NESH) binding protein
HGNC id	17265

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q12.2      Physical location : 100.468.180 - 100.712.334
Synonym name	target of NESH-SH3
	ABI gene family, member 3 (NESH) binding protein
	Nesh-binding protein
Synonym symbol(s)	TARSH, NESHBP, FLJ41743, FLJ41754, DKFZP586L2024

DNA

TYPE	functioning gene
STRUCTURE	244.14 kb     35 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 35 - 4488 isoform 1 118.5 1075 - Matsuda (2001)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessel         Endocrine thyroid       highly Respiratory lung       highly   respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two fibronectin type 3 domain
	one nuclear targeting sequence
	one SH3 binding motif

HOMOLOGY

Homologene

FAMILY

ABI family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	represents a trigger gene for evoking cellular senescence
	involved in the prevention of tumorigenesis
	plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development (Wakoh 2009)
	may plays a role in tumor suppression (Wakoh 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

probably interacting with ABI3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in lung cancer tumoral     --low   reduced expression led to the dysfunction of G1/S transition in cell cycle, which may have partially caused the growth inhibition in replicative senescence (Wakoh 2009) tumoral     --low   in most malignant thyroid tumors of all types (Latini 2008)

Susceptibility

Variant & Polymorphism

Candidate gene	biomarker for lung cancer development as well as a molecular adjunct for lung carcinogenesis in human
Marker
Therapy target	Activation of ABI3BP or its pathway may represent a possible basis for targeted therapy of certain cancers (Latini 2008)

ANIMAL & CELL MODELS