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FLASH GENE
Symbol ABI3BP contributors: mct/npt - updated : 11-07-2009
HGNC name ABI family, member 3 (NESH) binding protein
HGNC id 17265
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fibronectin type 3 domain
  • one nuclear targeting sequence
  • one SH3 binding motif
    • HOMOLOGY
    Homologene
    FAMILY
  • ABI family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • represents a trigger gene for evoking cellular senescence
  • involved in the prevention of tumorigenesis
  • plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development (Wakoh 2009)
  • may plays a role in tumor suppression (Wakoh 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • probably interacting with ABI3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer
    tumoral     --low  
    reduced expression led to the dysfunction of G1/S transition in cell cycle, which may have partially caused the growth inhibition in replicative senescence (Wakoh 2009)
    tumoral     --low  
    in most malignant thyroid tumors of all types (Latini 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene biomarker for lung cancer development as well as a molecular adjunct for lung carcinogenesis in human
    Marker
    Therapy target Activation of ABI3BP or its pathway may represent a possible basis for targeted therapy of certain cancers (Latini 2008)
    ANIMAL & CELL MODELS