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FLASH GENE
Symbol ABI3BP contributors: mct/npt - updated : 11-07-2009
HGNC name ABI family, member 3 (NESH) binding protein
HGNC id 17265
DNA
TYPE functioning gene
STRUCTURE 244.14 kb     35 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
35 - 4488 118.5 1075 - Matsuda (2001)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel    
Endocrinethyroid   highly
Respiratorylung   highly
 respiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two fibronectin type 3 domain
  • one nuclear targeting sequence
  • one SH3 binding motif
  • HOMOLOGY
    Homologene
    FAMILY
  • ABI family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • represents a trigger gene for evoking cellular senescence
  • involved in the prevention of tumorigenesis
  • plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development (Wakoh 2009)
  • may plays a role in tumor suppression (Wakoh 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • probably interacting with ABI3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer
    tumoral     --low  
    reduced expression led to the dysfunction of G1/S transition in cell cycle, which may have partially caused the growth inhibition in replicative senescence (Wakoh 2009)
    tumoral     --low  
    in most malignant thyroid tumors of all types (Latini 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene biomarker for lung cancer development as well as a molecular adjunct for lung carcinogenesis in human
    Marker
    Therapy target Activation of ABI3BP or its pathway may represent a possible basis for targeted therapy of certain cancers (Latini 2008)
    ANIMAL & CELL MODELS