Symbol
| BRD7
| contributors: mct/pgu - updated : 30-01-2024
|
HGNC name
| bromodomain containing 7
|
HGNC id
| 14310
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
|  
|  
| --low
|  
|
may provide an additional mechanism to antagonize TP53 function in cancer cells | constitutional
|  
|  
| --low
|  
|
lead to increased weight gain with little effect on glucose metabolism | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| DNA methylation of BRD7 promoter might serve as a diagnostic marker in nasopharyngeal carcinoma | |
is a promising candidate biomarker in breast cancer | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | head and neck | | |
targeting the BRD7/BIRC2 regulation axis might be a potential strategy for the diagnosis and treatment of nasopharyngeal carcinoma (NPC) | cancer | digestive | liver | |
may be a novel molecular target for the treatment of hepatocellular carcinoma (HCC) |
| | |
| Brd7 is significantly reduced in the liver of obese mice | |
homozygous Brd7 knockout (KO) mice showed retardation in development, and eventually all Brd7 KO embryos died in utero prior to E16.5 |