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FLASH GENE
Symbol BRD7 contributors: mct/pgu - updated : 30-01-2024
HGNC name bromodomain containing 7
HGNC id 14310
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
may provide an additional mechanism to antagonize TP53 function in cancer cells
constitutional     --low  
lead to increased weight gain with little effect on glucose metabolism
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • DNA methylation of BRD7 promoter might serve as a diagnostic marker in nasopharyngeal carcinoma
  • is a promising candidate biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    targeting the BRD7/BIRC2 regulation axis might be a potential strategy for the diagnosis and treatment of nasopharyngeal carcinoma (NPC)
    cancerdigestiveliver
    may be a novel molecular target for the treatment of hepatocellular carcinoma (HCC)
    ANIMAL & CELL MODELS
  • Brd7 is significantly reduced in the liver of obese mice
  • homozygous Brd7 knockout (KO) mice showed retardation in development, and eventually all Brd7 KO embryos died in utero prior to E16.5