basic FUNCTION
| protein that inhibits cell growth and cell cycle progression by transcriptional regulation of some cell cycle-related genes |
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playing a role in signal-dependent transcriptional regulation |
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having an important role in transcriptional regulation and cellular events including cell cycle |
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required for target gene activation and repression in embryonic stem cells |
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plays a critical role in cellular growth, cell cycle progression, and signal-dependent gene expression |
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suppressing tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogee-induced senescence |
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BRD7 and PBRM1 are unique regulators of replicative senescence in human cells |
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role in PRMT5-induced transcriptional silencing, and recruitment of specific RDMs and KDMs is required for efficient transcriptional derepression |
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might play a critical role in the regulation of synaptic plasticity and affect cognitive behavior |
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BRD7 has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NFKB1 signaling pathway |
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plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted |