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FLASH GENE
Symbol BRD7 contributors: mct/pgu - updated : 30-01-2024
HGNC name bromodomain containing 7
HGNC id 14310
DNA
TYPE functioning gene
STRUCTURE 49.92 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure transcriptional factor Sp1, E2F, and E2F-6 are associated in the BRD7 promoter region and regulate BRD7 promoter activity
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2227 74.1 651 - 2008 18809673
  • isoform 2
  • 17 - 2330 - 652 - 2008 18809673
  • isoform 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two bromodomains
  • a bromodomain interactingwith acetylated histone H3, potentially providing additional tethering of the PBAF complex to transcriptionally active chromatin
  • HOMOLOGY
    interspecies homolog to murine Brd7 (88.2pc)
    homolog to rattus Brd7 (88.0pc)
    Homologene
    FAMILY bromodomain-containing protein family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • predominantly localized in the nucleus, wherein it functions as a transcriptional regulator
  • basic FUNCTION
  • protein that inhibits cell growth and cell cycle progression by transcriptional regulation of some cell cycle-related genes
  • playing a role in signal-dependent transcriptional regulation
  • having an important role in transcriptional regulation and cellular events including cell cycle
  • required for target gene activation and repression in embryonic stem cells
  • plays a critical role in cellular growth, cell cycle progression, and signal-dependent gene expression
  • suppressing tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogee-induced senescence
  • BRD7 and PBRM1 are unique regulators of replicative senescence in human cells
  • role in PRMT5-induced transcriptional silencing, and recruitment of specific RDMs and KDMs is required for efficient transcriptional derepression
  • might play a critical role in the regulation of synaptic plasticity and affect cognitive behavior
  • BRD7 has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NFKB1 signaling pathway
  • plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • BRD7/GSK3B/NFE2L2 axis may play a key role in mediating podocyte injury in diabetic nephropathy
  • a component
  • component of the Polybromo-associated SMARCA4-associated factor (PBAF) complex in both embryonic stem cells (ESCs)and differentiated cells
  • potential PBAF-specific subunit
  • component of SWI-SNF complexes that interacts with PRMT5 on 'suppressor of tumorigenecity 7 (ST7) and retinoblastoma-like protein 2 (RBL2)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDZ domain of protein tyrosine phosphatase-BAS-like (PTP-BL) protein
  • interacting with BRD2, a putative BRD7-interacting protein (could interact with BRD2 and the region from amino acid 430 to 798 of BRD2 was critical for the interaction of BRD2 with BRD7)
  • MYC is indeed a negative regulator of BRD7 gene
  • TRIM24 binds to BRD7, which can negatively regulate cell proliferation and growth (TRIM24 regulates AR-mediated transcription in collaboration with KAT5 and BRD7)
  • binds directly to BRCA1 and regulates BRCA1-dependent transcription
  • interacts with PRMT5, and is involved in transcriptional repression of its target genes
  • BRD7 regulates XBP1 activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K
  • XAF1 is involved in BRD7-associated senescence and plays an important role in the regulation of endothelial senescence through a TP53-dependent pathway. 8)
  • SEH1L regulates oligodendrocyte progenitor cells (OPCs) differentiation by assembling OLIG2 and BRD7 into a transcription complex at nuclear periphery
  • BRD7 suppresses tumor growth and metastasis thus functioning as a tumor suppressor at least partially by negatively regulating the enhancer activity and expression of BIRC2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    may provide an additional mechanism to antagonize TP53 function in cancer cells
    constitutional     --low  
    lead to increased weight gain with little effect on glucose metabolism
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • DNA methylation of BRD7 promoter might serve as a diagnostic marker in nasopharyngeal carcinoma
  • is a promising candidate biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    targeting the BRD7/BIRC2 regulation axis might be a potential strategy for the diagnosis and treatment of nasopharyngeal carcinoma (NPC)
    cancerdigestiveliver
    may be a novel molecular target for the treatment of hepatocellular carcinoma (HCC)
    ANIMAL & CELL MODELS
  • Brd7 is significantly reduced in the liver of obese mice
  • homozygous Brd7 knockout (KO) mice showed retardation in development, and eventually all Brd7 KO embryos died in utero prior to E16.5