Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BRD7 contributors: mct/pgu - updated : 30-01-2024
HGNC name bromodomain containing 7
HGNC id 14310
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two bromodomains
  • a bromodomain interactingwith acetylated histone H3, potentially providing additional tethering of the PBAF complex to transcriptionally active chromatin
    • HOMOLOGY
    interspecies homolog to murine Brd7 (88.2pc)
    homolog to rattus Brd7 (88.0pc)
    Homologene
    FAMILY bromodomain-containing protein family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • predominantly localized in the nucleus, wherein it functions as a transcriptional regulator
    • basic FUNCTION
  • protein that inhibits cell growth and cell cycle progression by transcriptional regulation of some cell cycle-related genes
  • playing a role in signal-dependent transcriptional regulation
  • having an important role in transcriptional regulation and cellular events including cell cycle
  • required for target gene activation and repression in embryonic stem cells
  • plays a critical role in cellular growth, cell cycle progression, and signal-dependent gene expression
  • suppressing tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogee-induced senescence
  • BRD7 and PBRM1 are unique regulators of replicative senescence in human cells
  • role in PRMT5-induced transcriptional silencing, and recruitment of specific RDMs and KDMs is required for efficient transcriptional derepression
  • might play a critical role in the regulation of synaptic plasticity and affect cognitive behavior
  • BRD7 has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NFKB1 signaling pathway
  • plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted
    • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • BRD7/GSK3B/NFE2L2 axis may play a key role in mediating podocyte injury in diabetic nephropathy
    • a component
  • component of the Polybromo-associated SMARCA4-associated factor (PBAF) complex in both embryonic stem cells (ESCs)and differentiated cells
  • potential PBAF-specific subunit
  • component of SWI-SNF complexes that interacts with PRMT5 on 'suppressor of tumorigenecity 7 (ST7) and retinoblastoma-like protein 2 (RBL2)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDZ domain of protein tyrosine phosphatase-BAS-like (PTP-BL) protein
  • interacting with BRD2, a putative BRD7-interacting protein (could interact with BRD2 and the region from amino acid 430 to 798 of BRD2 was critical for the interaction of BRD2 with BRD7)
  • MYC is indeed a negative regulator of BRD7 gene
  • TRIM24 binds to BRD7, which can negatively regulate cell proliferation and growth (TRIM24 regulates AR-mediated transcription in collaboration with KAT5 and BRD7)
  • binds directly to BRCA1 and regulates BRCA1-dependent transcription
  • interacts with PRMT5, and is involved in transcriptional repression of its target genes
  • BRD7 regulates XBP1 activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K
  • XAF1 is involved in BRD7-associated senescence and plays an important role in the regulation of endothelial senescence through a TP53-dependent pathway. 8)
  • SEH1L regulates oligodendrocyte progenitor cells (OPCs) differentiation by assembling OLIG2 and BRD7 into a transcription complex at nuclear periphery
  • BRD7 suppresses tumor growth and metastasis thus functioning as a tumor suppressor at least partially by negatively regulating the enhancer activity and expression of BIRC2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    may provide an additional mechanism to antagonize TP53 function in cancer cells
    constitutional     --low  
    lead to increased weight gain with little effect on glucose metabolism
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • DNA methylation of BRD7 promoter might serve as a diagnostic marker in nasopharyngeal carcinoma
  • is a promising candidate biomarker in breast cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    targeting the BRD7/BIRC2 regulation axis might be a potential strategy for the diagnosis and treatment of nasopharyngeal carcinoma (NPC)
    cancerdigestiveliver
    may be a novel molecular target for the treatment of hepatocellular carcinoma (HCC)
    ANIMAL & CELL MODELS
  • Brd7 is significantly reduced in the liver of obese mice
  • homozygous Brd7 knockout (KO) mice showed retardation in development, and eventually all Brd7 KO embryos died in utero prior to E16.5