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FLASH GENE
Symbol BRD7 contributors: mct/pgu - updated : 27-10-2012
HGNC name bromodomain containing 7
HGNC id 14310
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two bromodomains
  • a bromodomain interactingwith acetylated histone H3, potentially providing additional tethering of the PBAF complex to transcriptionally active chromatin
  • HOMOLOGY
    interspecies homolog to murine Brd7 (88.2pc)
    homolog to rattus Brd7 (88.0pc)
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • protein that inhibits cell growth and cell cycle progression by transcriptional regulation of some cell cycle-related genes
  • playing a role in signal-dependent transcriptional regulation
  • having an important role in transcriptional regulation and cellular events including cell cycle
  • required for target gene activation and repression in embryonic stem cells
  • plays a critical role in cellular growth, cell cycle progression, and signal-dependent gene expression
  • suppressing tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogee-induced senescence
  • BRD7 and PBRM1 are unique regulators of replicative senescence in human cells
  • role in PRMT5-induced transcriptional silencing, and recruitment of specific RDMs and KDMs is required for efficient transcriptional derepression
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Polybromo-associated SMARCA4-associated factor (PBAF) complex in both embryonic stem cells (ESCs)and differentiated cells
  • potential PBAF-specific subunit
  • component of SWI-SNF complexes that interacts with PRMT5 on 'suppressor of tumorigenecity 7 (ST7) and retinoblastoma-like protein 2 (RBL2)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDZ domain of protein tyrosine phosphatase-BAS-like (PTP-BL) protein
  • interacting with BRD2, a putative BRD7-interacting protein (could interact with BRD2 and the region from amino acid 430 to 798 of BRD2 was critical for the interaction of BRD2 with BRD7)
  • MYC is indeed a negative regulator of BRD7 gene
  • TRIM24 binds to BRD7, which can negatively regulate cell proliferation and growth (TRIM24 regulates AR-mediated transcription in collaboration with KAT5 and BRD7)
  • binds directly to BRCA1 and regulates BRCA1-dependent transcription
  • interacts with PRMT5, and is involved in transcriptional repression of its target genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    may provide an additional mechanism to antagonize TP53 function in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • DNA methylation of BRD7 promoter might serve as a diagnostic marker in nasopharyngeal carcinoma (
  • Therapy target
    ANIMAL & CELL MODELS