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FLASH GENE
Symbol BRD7 contributors: mct/pgu - updated : 27-10-2012
HGNC name bromodomain containing 7
HGNC id 14310
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2227 74.1 651 - 2008 18809673
  • isoform 2
  • 17 - 2330 - 652 - 2008 18809673
  • isoform 1
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two bromodomains
  • a bromodomain interactingwith acetylated histone H3, potentially providing additional tethering of the PBAF complex to transcriptionally active chromatin
  • HOMOLOGY
    interspecies homolog to murine Brd7 (88.2pc)
    homolog to rattus Brd7 (88.0pc)
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • protein that inhibits cell growth and cell cycle progression by transcriptional regulation of some cell cycle-related genes
  • playing a role in signal-dependent transcriptional regulation
  • having an important role in transcriptional regulation and cellular events including cell cycle
  • required for target gene activation and repression in embryonic stem cells
  • plays a critical role in cellular growth, cell cycle progression, and signal-dependent gene expression
  • suppressing tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogee-induced senescence
  • BRD7 and PBRM1 are unique regulators of replicative senescence in human cells
  • role in PRMT5-induced transcriptional silencing, and recruitment of specific RDMs and KDMs is required for efficient transcriptional derepression
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Polybromo-associated SMARCA4-associated factor (PBAF) complex in both embryonic stem cells (ESCs)and differentiated cells
  • potential PBAF-specific subunit
  • component of SWI-SNF complexes that interacts with PRMT5 on 'suppressor of tumorigenecity 7 (ST7) and retinoblastoma-like protein 2 (RBL2)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDZ domain of protein tyrosine phosphatase-BAS-like (PTP-BL) protein
  • interacting with BRD2, a putative BRD7-interacting protein (could interact with BRD2 and the region from amino acid 430 to 798 of BRD2 was critical for the interaction of BRD2 with BRD7)
  • MYC is indeed a negative regulator of BRD7 gene
  • TRIM24 binds to BRD7, which can negatively regulate cell proliferation and growth (TRIM24 regulates AR-mediated transcription in collaboration with KAT5 and BRD7)
  • binds directly to BRCA1 and regulates BRCA1-dependent transcription
  • interacts with PRMT5, and is involved in transcriptional repression of its target genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    may provide an additional mechanism to antagonize TP53 function in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • DNA methylation of BRD7 promoter might serve as a diagnostic marker in nasopharyngeal carcinoma (
  • Therapy target
    ANIMAL & CELL MODELS